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Reference List (1)Moore R. Medical Foods for
Celiac Disease. Lifeline XV [3], 1-11. 7-1-1997. (2)Arnal JF, Dinh-Xuan AT, Pueyo M, Darblade B, Rami J. Endothelium-derived nitric oxide and vascular physiology and pathology. Cell Mol Life Sci 1999 July;55(8-9):1078-87. (3)Bocchi EA, Vilella de Moraes AV, Esteves-Filho A et al. L-arginine reduces heart rate and improves hemodynamics in severe congestive heart failure. Clin Cardiol 2000 March;23(3):205-10. (4)Bode-Boger SM, Boger RH, Loffler M, Tsikas D, Brabant G, Frolich JC. L-arginine stimulates NO-dependent vasodilation in healthy humans--effect of somatostatin pretreatment. J Investig Med 1999 January;47(1):43-50. (5)Bradamante S, Barenghi L, Piccinini F et al. Resveratrol provides late-phase cardioprotection by means of a nitric oxide- and adenosine-mediated mechanism. Eur J Pharmacol 2003 March 28;465(1-2):115-23. (6)Cremona G, Wood AM, Hall LW, Bower EA, Higenbottam T. Effect of inhibitors of nitric oxide release and action on vascular tone in isolated lungs of pig, sheep, dog and man. J Physiol 1994 November 15;481 ( Pt 1):185-95. (7)Fagan JM, Rex SE, Hayes-Licitra SA, Waxman L. L-arginine reduces right heart hypertrophy in hypoxia-induced pulmonary hypertension. Biochem Biophys Res Commun 1999 January 8;254(1):100-3. (8)Fineman JR, Chang R, Soifer SJ. L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs. Am J Physiol 1991 November;261(5 Pt 2):H1563-H1569. (9)Heller A, Ragaller M, Schmeck J et al. Role of NO and endothelin in hemoglobin-induced pulmonary vasoconstriction. Shock 1998 December;10(6):401-6. (10)Kaputlu I, Sadan G. Evidence that nitric oxide mediates non-adrenergic non-cholinergic relaxation induced by GABA and electrical stimulation in the rat isolated duodenum. J Auton Pharmacol 1996 August;16(4):177-82. (11)Kavvadia V, Greenough A, Lilley J et al. Plasma arginine levels and the response to inhaled nitric oxide in neonates. Biol Neonate 1999 December;76(6):340-7. (12)Kilbourn RG. Nitric oxide: moving towards the clinic. Mol Med Today 1996 August;2(8):324. (13)Korbonits M, Trainer PJ, Fanciulli G et al. L-arginine is unlikely to exert neuroendocrine effects in humans via the generation of nitric oxide. Eur J Endocrinol 1996 November;135(5):543-7. (14)Kostic MM, Petronijevic MR, Jakovljevic VL. Role of nitric oxide (NO) in the regulation of coronary circulation. Physiol Res 1996;45(4):273-8. (15)Lefevere L, Willems T, Lindberg S, Jorissen M. Nasal nitric oxide. Acta Otorhinolaryngol Belg 2000;54(3):271-80. (16)Song MS, Shin KA, Kang JS et al. The involvement of nitric oxide on the adenosine A(2) receptor-induced cardiovascular inhibitory responses in the posterior hypothalamus of rats. Neurosci Lett 2002 June 21;326(1):41-5. (17)Stuhlinger MC, Tsao PS, Her JH, Kimoto M, Balint RF, Cooke JP. Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation 2001 November 20;104(21):2569-75. (18)Truog WE, Norberg M, Thibeault DW. Effect of inhaled nitric oxide in endothelin-1-induced pulmonary hypertension. Biol Neonate 1998;73(4):246-53. (19)Wu G, Meininger CJ. Arginine nutrition and cardiovascular function. J Nutr 2000 November;130(11):2626-9. (20)Yamada T, Yukioka H, Hayashi M, Asada A, Inoue M. Effects of inhaled nitric oxide on platelet-activating factor-induced pulmonary hypertension in dogs. Acta Anaesthesiol Scand 1998 March;42(3):358-68. (21)Albrecht EW, Stegeman CA, Heeringa P, Henning RH, van GH. Protective role of endothelial nitric oxide synthase. J Pathol 2003 January;199(1):8-17. (22)Alexander BT, Llinas MT, Kruckeberg WC, Granger JP. L-arginine attenuates hypertension in pregnant rats with reduced uterine perfusion pressure. Hypertension 2004 April;43(4):832-6. (23)Araujo MT, Barker LA, Cabral AM, Vasquez EC. Inhibition of nitric oxide synthase causes profound enhancement of the Bezold-Jarisch reflex. Am J Hypertens 1998 January;11(1 Pt 1):66-72. (24)Arnal JF, nh-Xuan AT, Pueyo M, Darblade B, Rami J. Endothelium-derived nitric oxide and vascular physiology and pathology. Cell Mol Life Sci 1999 July;55(8-9):1078-87. (25)Asanuma H, Minamino T, Sanada S et al. A calcium channel blocker amlodipine increases coronary blood flow via both adenosine- and NO-dependent mechanisms in ischemic hearts. J Mol Cell Cardiol 2005 October;39(4):605-14. (26)Augustyniak RA, Thomas GD, Victor RG, Zhang W. Nitric oxide pathway as new drug targets for refractory hypertension. Curr Pharm Des 2005;11(25):3307-15. (27)Bartholomeusz B, Hardy KJ, Nelson AS, Phillips PA. Modulation of nitric oxide improves cyclosporin A-induced hypertension in rats and primates. J Hum Hypertens 1998 December;12(12):839-44. (28)Bassenge E. Clinical relevance of endothelium-derived relaxing factor (EDRF). Br J Clin Pharmacol 1992;34 Suppl 1:37S-42S. (29)Baylis C, Bloch J. Nitric oxide (NO) in renal physiology and pathophysiology. Nephrol Dial Transplant 1996 October;11(10):1955-7. (30)Benjamin N, Vane J. Nitric oxide and hypertension. Circulation 1996 September 15;94(6):1197-8. (31)Boger RH, Bode-Boger SM, Matsuoka H et al. Is asymmetric dimethylarginine a novel marker of atherosclerosis? Circulation 2000 April 11;101(14):E160-E161. (32)Bolad I, Delafontaine P. Endothelial dysfunction: its role in hypertensive coronary disease. Curr Opin Cardiol 2005 July;20(4):270-4. (33)Brands MW, Cloud LJ. Control of arterial pressure by angiotensin II and nitric oxide at the onset of diabetes. Am J Hypertens 2003 July;16(7):600-3. (34)Britten MB, Zeiher AM, Schachinger V. Clinical importance of coronary endothelial vasodilator dysfunction and therapeutic options. J Intern Med 1999 April;245(4):315-27. (35)Cachofeiro V, Maeso R, Munoz-Garcia R, Lahera V. The potential role of nitric oxide in angiotensin II-receptor blockade. Blood Press Suppl 1996;2:29-35. (36)Campo C, Lahera V, Garcia-Robles R et al. Aging abolishes the renal response to L-arginine infusion in essential hypertension. Kidney Int Suppl 1996 June;55:S126-S128. (37)Caramia F, Yoshida T, Hamberg LM et al. Measurement of changes in cerebral blood volume in spontaneously hypertensive rats following L-arginine infusion using dynamic susceptibility contrast MRI. Magn Reson Med 1998 January;39(1):160-3. (38)Carnio EC, Branco LG. Participation of the nitric oxide pathway in cold-induced hypertension. Life Sci 1997;60(21):1875-80. (39)Chang HR, Wu CY, Hsu YH, Chen HI. Reduction of ventricular hypertrophy and fibrosis in spontaneously hypertensive rats by L-arginine. Chin J Physiol 2005 March 31;48(1):15-22. (40)Cleland SJ, Petrie JR, Small M, Elliott HL, Connell JM. Insulin action is associated with endothelial function in hypertension and type 2 diabetes. Hypertension 2000 January;35(1 Pt 2):507-11. (41)Cooke JP, Losordo DW. Nitric oxide and angiogenesis. Circulation 2002 May 7;105(18):2133-5. (42)Cooke JP, Oka RK. Atherogenesis and the arginine hypothesis. Curr Atheroscler Rep 2001 May;3(3):252-9. (43)Cooke JP. Is atherosclerosis an arginine deficiency disease? J Investig Med 1998 October;46(8):377-80. (44)Cooke JP, Dzau VJ. Derangements of the nitric oxide synthase pathway, L-arginine, and cardiovascular diseases. Circulation 1997 July 15;96(2):379-82. (45)Creager MA, Gallagher SJ, Girerd XJ, Coleman SM, Dzau VJ, Cooke JP. L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest 1992 October;90(4):1248-53. (46)Dalla VM, Sacerdoti D, Bombonato G et al. Nitric oxide modulation of renal and cardiac hemodynamics in type 2 diabetes. Eur J Endocrinol 2002 May;146(5):687-94. (47)Drexler H. Endothelial dysfunction: clinical implications. Prog Cardiovasc Dis 1997 January;39(4):287-324. (48)Dubey RK, Boegehold MA, Gillespie DG, Rosselli M. Increased nitric oxide activity in early renovascular hypertension. Am J Physiol 1996 January;270(1 Pt 2):R118-R124. (49)Edmunds NJ, Moncada S, Marshall JM. Does nitric oxide allow endothelial cells to sense hypoxia and mediate hypoxic vasodilatation? In vivo and in vitro studies. J Physiol 2003 January 15;546(Pt 2):521-7. (50)Fitzgerald SM, Brands MW. Hypertension in L-NAME-treated diabetic rats depends on an intact sympathetic nervous system. Am J Physiol Regul Integr Comp Physiol 2002 April;282(4):R1070-R1076. (51)Fitzgerald SM, Brands MW. Nitric oxide may be required to prevent hypertension at the onset of diabetes. Am J Physiol Endocrinol Metab 2000 October;279(4):E762-E768. (52)Forte P, Copland M, Smith LM, Milne E, Sutherland J, Benjamin N. Basal nitric oxide synthesis in essential hypertension. Lancet 1997 March 22;349(9055):837-42. (53)Gardiner SM, Dunn WR, Bennett T. Chronic nitric oxide inhibition model six years on. Hypertension 1999 November;34(5):e4. (54)Girerd XJ, Hirsch AT, Cooke JP, Dzau VJ, Creager MA. L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits. Circ Res 1990 December;67(6):1301-8. (55)Gokce N. L-arginine and hypertension. J Nutr 2004 October;134(10 Suppl):2807S-11S. (56)Haulica I, Cosovanu A, Ungureanu G, Zaharia D, Baltatu O, Boisteanu D. Cardiovascular effects of L-arginine as physiological precursor of nitric oxide. Rom J Intern Med 1994 July;32(3):195-201. (57)Hayakawa H, Hirata Y, Suzuki E et al. Long-term administration of L-arginine improves nitric oxide release from kidney in deoxycorticosterone acetate-salt hypertensive rats. Hypertension 1994 June;23(6 Pt 1):752-6. (58)Herlitz H, Jungersten LU, Wikstrand J, Widgren BR. Effect of L-arginine infusion in normotensive subjects with and without a family history of hypertension. Kidney Int 1999 November;56(5):1838-45. (59)Hishikawa K, Nakaki T, Suzuki H, Kato R, Saruta T. Role of L-arginine-nitric oxide pathway in hypertension. J Hypertens 1993 June;11(6):639-45. (60)Hutchison SJ, Sudhir K, Sievers RE et al. Effects of L-arginine on atherogenesis and endothelial dysfunction due to secondhand smoke. Hypertension 1999 July;34(1):44-50. (61)Johnson RA, Freeman RH. Sustained hypertension in the rat induced by chronic blockade of nitric oxide production. Am J Hypertens 1992 December;5(12 Pt 1):919-22. (62)Jover B, Herizi A, Ventre F, Dupont M, Mimran A. Sodium and angiotensin in hypertension induced by long-term nitric oxide blockade. Hypertension 1993 June;21(6 Pt 2):944-8. (63)Kelm M. The L-arginine-nitric oxide pathway in hypertension. Curr Hypertens Rep 2003 February;5(1):80-6. (64)Kilbourn RG. Nitric oxide: moving towards the clinic. Mol Med Today 1996 August;2(8):324. (65)Lefebvre RA, Smits GJ, Timmermans JP. Study of NO and VIP as non-adrenergic non-cholinergic neurotransmitters in the pig gastric fundus. Br J Pharmacol 1995 October;116(3):2017-26. (66)Lin KY, Ito A, Asagami T et al. Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation 2002 August 20;106(8):987-92. (67)Llorens S, Nava E. Cardiovascular diseases and the nitric oxide pathway. Curr Vasc Pharmacol 2003 October;1(3):335-46. (68)Luscher TF. Heterogeneity of endothelial dysfunction in hypertension. Eur Heart J 1992 September;13 Suppl D:50-5. (69)Luscher TF, Bock HA. The endothelial L-arginine/nitric oxide pathway and the renal circulation. Klin Wochenschr 1991 September 3;69(13):603-9. (70)MacAllister R, Vallance P. Nitric oxide in essential and renal hypertension. J Am Soc Nephrol 1994 October;5(4):1057-65. (71)[Beta blocker enhances NO liberation in the endothelium. Vascular tone long-term improvement]. MMW Fortschr Med 2002 December 5;144(49):59. (72)Abeywardena MY, Head RJ. Dietary polyunsaturated fatty acid and antioxidant modulation of vascular dysfunction in the spontaneously hypertensive rat. Prostaglandins Leukot Essent Fatty Acids 2001 August;65(2):91-7. (73)Angus JA, Lew MJ. Interpretation of the acetylcholine test of endothelial cell dysfunction in hypertension. J Hypertens Suppl 1992 December;10(7):S179-S186. (74)Boulanger CM. Secondary endothelial dysfunction: hypertension and heart failure. J Mol Cell Cardiol 1999 January;31(1):39-49. (75)Brezenoff HE, Xiao YF. Acetylcholine in the posterior hypothalamic nucleus is involved in the elevated blood pressure in the spontaneously hypertensive rat. Life Sci 1989;45(13):1163-70. (76)Cardillo C, Kilcoyne CM, Quyyumi AA, Cannon RO, III, Panza JA. Selective defect in nitric oxide synthesis may explain the impaired endothelium-dependent vasodilation in patients with essential hypertension. Circulation 1998 March 10;97(9):851-6. (77)de Wardener HE. The hypothalamus and hypertension. Physiol Rev 2001 October;81(4):1599-658. (78)Gerova M. Acetylcholine and bradykinin induce paradoxically amplified hypotensive response in hypertensive NO-deficient rats. Physiol Res 1999;48(4):249-57. (79)Granstam SO, Granstam E, Fellstrom B, Lind L. Effects of acetylcholine and nitroprusside on systemic and regional hemodynamics in hypertensive rats. Clin Exp Hypertens 1998 February;20(2):223-43. (80)Higashi Y, Nakagawa K, Kimura M et al. Circadian variation of blood pressure and endothelial function in patients with essential hypertension:a comparison of dippers and non-dippers. J Am Coll Cardiol 2002 December 4;40(11):2039-43. (81)Imaoka Y, Osanai T, Kamada T, Mio Y, Satoh K, Okumura K. Nitric oxide-dependent vasodilator mechanism is not impaired by hypertension but is diminished with aging in the rat aorta. J Cardiovasc Pharmacol 1999 May;33(5):756-61. (82)Kamata K, Yamashita K. Insulin resistance and impaired endothelium-dependent renal vasodilatation in fructose-fed hypertensive rats. Res Commun Mol Pathol Pharmacol 1999 February;103(2):195-210. (83)Li P, Zhu DN, Kao KM, Lin Q, Sun SY. Role of acetylcholine, corticoids and opioids in the rostral ventrolateral medulla in stress-induced hypertensive rats. Biol Signals 1995 May;4(3):124-32. (84)Lockette W, Otsuka Y, Carretero O. The loss of endothelium-dependent vascular relaxation in hypertension. Hypertension 1986 June;8(6 Pt 2):II61-II66. (85)McCaughran JA, Jr., Edwards E, Friedman R, Schechter N. Myocardial cholinergic receptor sites and enzyme activity in the Dahl model of essential hypertension. Clin Exp Hypertens A 1984;6(4):811-26. (86)Quilley J, Fulton D, McGiff JC. The position of NO among endogenous vasodilators. Pol J Pharmacol 1994 November;46(6):523-30. (87)Taddei S, Virdis A, Ghiadoni L et al. Age-related reduction of NO availability and oxidative stress in humans. Hypertension 2001 August;38(2):274-9. (88)Tominaga M, Fujii K, Abe I, Takata Y, Kobayashi K, Fujishima M. Hypertension and ageing impair acetylcholine-induced vasodilation in rats. J Hypertens 1994 March;12(3):259-68. (89)Emery CJ, Teng GQ, Liu X, Barer GR. Vasoreactions to acute hypoxia, whole lungs and isolated vessels compared: modulation by NO. Respir Physiolo Neurobiol 2003 March 3;134(2):115-29. (90)Heinonen E, Merilainen P, Hogman M. Administration of nitric oxide into open lung regions: delivery and monitoring. Br J Anaesth 2003 March;90(3):338-42. (91)Aranda M, Pearl RG. Inhaled nitric oxide and pulmonary vasoreactivity. J Clin Monit Comput 2000;16(5-6):393-401. (92)Fesler P, Pagnamenta A, Vachiery JL et al. Single arterial occlusion to locate resistance in patients with pulmonary hypertension. Eur Respir J 2003 January;21(1):31-6. (93)Kao SJ, Peng TC, Lee RP et al. Nitric oxide mediates lung injury induced by ischemia-reperfusion in rats. J Biomed Sci 2003;10(1):58-64. (94)Kaftan HA, Clark PL, Norberg M, Garg U, Thibeault DW, Truog WE. Endogenous production of nitric oxide in endotoxemic piglets. Biol Neonate 2003;83(1):42-8. (95)Lee ML, Chiu IS. Inhaled nitric oxide for persistent pulmonary hypertension in a neonate with pulmonary atresia and intact ventricular septum after radiofrequency valvulotomy, balloon valvuloplasty and Blalock-Taussig shunt. Int J Cardiol 2003 February;87(2-3):273-7. (96)Galie N, Manes A, Branzi A. Emerging medical therapies for pulmonary arterial hypertension. Prog Cardiovasc Dis 2002 November;45(3):213-24. (97)Hurford WE. Inhaled nitric oxide. Respir Care Clin N Am 2002 June;8(2):261-79. (98)Gillies HC, Roblin D, Jackson G. Coronary and systemic hemodynamic effects of sildenafil citrate: from basic science to clinical studies in patients with cardiovascular disease. Int J Cardiol 2002 December;86(2-3):131-41. (99)Keefer LK. Progress toward clinical application of the nitric oxide-releasing diazeniumdiolates. Annu Rev Pharmacol Toxicol 2003;43:585-607. (100)Sitbon O, Humbert M, Simonneau G. Primary pulmonary hypertension: Current therapy. Prog Cardiovasc Dis 2002 September;45(2):115-28. (101)Jeh HS, Georg SC. Dynamic modeling and simulation of nitric oxide gas delivery to pulmonary arterioles. Ann Biomed Eng 2002 July;30(7):946-60. (102)Chen HI, Hu CT, Wu CY, Wang D. Nitric Oxide in Systemic and Pulmonary Hypertension. J Biomed Sci 1997;4(5):244-8. (103)Dweik RA. Pulmonary hypertension and the search for the selective pulmonary vasodilator. Lancet 2002 September 21;360(9337):886-7. (104)Lepore JJ, Maroo A, Pereira NL et al. Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension. Am J Cardiol 2002 September 15;90(6):677-80. (105)Lowson SM. Inhaled alternatives to nitric oxide. Anesthesiology 2002 June;96(6):1504-13. (106)Clini E, Ambrosino N. Nitric oxide and pulmonary circulation. Med Sci Monit 2002 August;8(8):RA178-RA182. (107)Huang KL, Wu CP, Kang BH, Lin YC. Chronic hypoxia attenuates nitric oxide-dependent hemodynamic responses to acute hypoxia. J Biomed Sci 2002 May;9(3):206-12. (108)Wilkins MR, Aldashev A, Morrell NW. Nitric oxide, phosphodiesterase inhibition, and adaptation to hypoxic conditions. Lancet 2002 May 4;359(9317):1539-40. (109)Trummer G, Berchtold-Herz M, Martin J, Beyersdorf F. Successful treatment of pulmonary hypertension with inhaled nitric oxide after pulmonary embolectomy. Ann Thorac Surg 2002 April;73(4):1299-301. (110)Hoeper MM, Galie N, Simonneau G, Rubin LJ. New treatments for pulmonary arterial hypertension. Am J Respir Crit Care Med 2002 May 1;165(9):1209-16. (111)Hida W, Tun Y, Kikuchi Y, Okabe S, Shirato K. Pulmonary hypertension in patients with chronic obstructive pulmonary disease: recent advances in pathophysiology and management. Respirology 2002 March;7(1):3-13. (112)Kemming G, Habler O, Kleen M, Kisch-Wedel H, Welte M, Zwissler B. Searching the ideal inhaled vasodilator: from nitric oxide to prostacyclin. Eur Surg Res 2002 January;34(1-2):196-202. (113)Deuchar GA, Docherty A, MacLean MR, Hicks MN. Pulmonary hypertension secondary to left ventricular dysfunction: the role of nitric oxide and endothelin-1 in the control of pulmonary vascular tone. Br J Pharmacol 2002 February;135(4):1060-8. (114)Maxey TS, Smith CD, Kern JA et al. Beneficial effects of inhaled nitric oxide in adult cardiac surgical patients. Ann Thorac Surg 2002 February;73(2):529-32. (115)Qi J, Du J, Wang L, Zhao B, Tang C. Alleviation of hypoxic pulmonary vascular structural remodeling by L-arginine. Chin Med J (Engl ) 2001 September;114(9):933-6. (116)Hayward CS, Macdonald PS, Keogh AM. Inhaled nitric oxide in cardiology. Expert Opin Investig Drugs 2001 November;10(11):1947-56. (117)Naeije R, Barbera JA. Pulmonary hypertension associated with COPD. Crit Care 2001 December;5(6):286-9. (118)Rashid A, Lehrman S, Romano P, Frishman W, Dobkin J, Reichel J. Primary pulmonary hypertension. Heart Dis 2000 November;2(6):422-30. (119)Gladwin MT, Schechter AN. Nitric oxide therapy in sickle cell disease. Semin Hematol 2001 October;38(4):333-42. (120)Gorenflo M, Zheng C, Poge A et al. Metabolites of the L-arginine-NO pathway in patients with left-to-right shunt. Clin Lab 2001;47(9-10):441-7. (121)Robbins IM, Barst RJ, Channick RN, Rubin LJ. Pulmonary vasoreactivity in PPH. J Am Coll Cardiol 2001 October;38(4):1267-8. (122)Braschi A, Iannuzzi M, Belliato M, Iotti GA. Therapeutic use of nitric oxide in critical settings. Monaldi Arch Chest Dis 2001 April;56(2):177-9. (123)Monnery L, Nanson J, Charlton G. Primary pulmonary hypertension in pregnancy; a role for novel vasodilators. Br J Anaesth 2001 August;87(2):295-8. (124)Cooke JP. A novel mechanism for pulmonary arterial hypertension? Circulation 2003 September 23;108(12):1420-1. (125)Cooke JP, Sydow K, Chen J, Huang P. A peculiar result and a fanciful hypothesis regarding L-arginine *. Arterioscler Thromb Vasc Biol 2003 June 1;23(6):1128. (126)Kandler MA, Von Der HK, Mahfoud S et al. Pilot intervention: aerosolized adrenomedullin reduces pulmonary hypertension. J Pharmacol Exp Ther 2003 September;306(3):1021-6. (127)Michelakis ED. The role of the NO axis and its therapeutic implications in pulmonary arterial hypertension. Heart Fail Rev 2003 January;8(1):5-21. (128)Millatt LJ, Whitley GS, Li D et al. Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension. Circulation 2003 September 23;108(12):1493-8. (129)Morris CR, Morris SM, Jr., Hagar W et al. Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease? Am J Respir Crit Care Med 2003 July 1;168(1):63-9. (130)Nagaoka T, Morio Y, Casanova N et al. Rho/Rho-kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 2003 September 5. (131)Peacock AJ. Treatment of pulmonary hypertension. BMJ 2003 April 19;326(7394):835-6. (132)Sander M, Welling KL, Ravn JB, Boberg B, Amtorp O. Endogenous NO does not regulate baseline pulmonary pressure, but reduces acute pulmonary hypertension in dogs. Acta Physiol Scand 2003 July;178(3):269-77. (133)Stuhlinger MC, Oka RK, Graf EE et al. Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine. Circulation 2003 August 26;108(8):933-8. (134)Asagami T, Abbasi F, Stuelinger M et al. Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes. Metabolism 2002 July;51(7):843-6. (135)Hoeper MM, Galie N, Simonneau G, Rubin LJ. New treatments for pulmonary arterial hypertension. Am J Respir Crit Care Med 2002 May 1;165(9):1209-16. (136)Lin KY, Ito A, Asagami T et al. Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation 2002 August 20;106(8):987-92. (137)Qi J, Du J, Wang L, Zhao B, Tang C. Alleviation of hypoxic pulmonary vascular structural remodeling by L-arginine. Chin Med J (Engl ) 2001 September;114(9):933-6. (138)Saidy K, al Alaiyan S. The use of L-arginine [correction of F-arginine] and phosphodiesterase inhibitor (dipyridamole) to wean from inhaled nitric oxide. Indian J Pediatr 2001 February;68(2):175-7. (139)Stuhlinger MC, Tsao PS, Her JH, Kimoto M, Balint RF, Cooke JP. Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation 2001 November 20;104(21):2569-75. (140)Vassalli F, Pierre S, Julien V, Bouckaert Y, Brimioulle S, Naeije R. Inhibition of hypoxic pulmonary vasoconstriction by carbon monoxide in dogs. Crit Care Med 2001 February;29(2):359-66. (141)Cooke JP. Does ADMA cause endothelial dysfunction? Arterioscler Thromb Vasc Biol 2000 September;20(9):2032-7. (142)Rashid A, Lehrman S, Romano P, Frishman W, Dobkin J, Reichel J. Primary pulmonary hypertension. Heart Dis 2000 November;2(6):422-30. (143)Roberts JD, Jr., Zapol WM. Inhaled nitric oxide. Semin Perinatol 2000 February;24(1):55-8. (144)Cooke JP. The 1998 Nobel prize in Medicine: clinical implications for 1999 and beyond. Vasc Med 1999;4(2):57-60. (145)Hutchison SJ, Sudhir K, Sievers RE et al. Effects of L-arginine on atherogenesis and endothelial dysfunction due to secondhand smoke. Hypertension 1999 July;34(1):44-50. (146)Kavvadia V, Greenough A, Lilley J et al. Plasma arginine levels and the response to inhaled nitric oxide in neonates. Biol Neonate 1999 December;76(6):340-7. (147)Maxwell AJ, Cooke JP. The role of nitric oxide in atherosclerosis. Coron Artery Dis 1999 July;10(5):277-86. (148)Sperling RT, Creager MA. Nitric oxide and pulmonary hypertension. Coron Artery Dis 1999 July;10(5):287-94. (149)Tangphao O, Chalon S, Coulston AM et al. L-arginine and nitric oxide-related compounds in plasma: comparison of normal and arginine-free diets in a 24-h crossover study. Vasc Med 1999;4(1):27-32. (150)Kannan MS, Guiang S, Johnson DE. Nitric oxide: biological role and clinical uses. Indian J Pediatr 1998 May;65(3):333-45. (151)Maxwell AJ, Cooke JP. Cardiovascular effects of L-arginine. Curr Opin Nephrol Hypertens 1998 January;7(1):63-70. (152)Moscato G, Malo JL, Bernstein D. Diagnosing occupational asthma: how, how much, how far? Eur Respir J 2003 May;21(5):879-85. (153)Covar RA, Szefler SJ, Martin RJ et al. Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma. J Pediatr 2003 May;142(5):469-75. (154)Lierl MB. Exhaled nitric oxide: a useful aide in pediatric asthma management? J Pediatr 2003 May;142(5):461-2. (155)Payne DN. Nitric oxide in allergic airway inflammation. Curr Opin Allergy Clin Immunol 2003 April;3(2):133-7. (156)Silvestri M, Sabatini F, Sale R et al. Correlations between exhaled nitric oxide levels, blood eosinophilia, and airway obstruction reversibility in childhood asthma are detectable only in atopic individuals. Pediatr Pulmonol 2003 May;35(5):358-63. (157)Prieto L, Gutierrez V, Uixera S, Bruno L. Concentrations of exhaled nitric oxide in asthmatics and subjects with allergic rhinitis sensitized to the same pollen allergen. Clin Exp Allergy 2002 December;32(12):1728-33. (158)Dupont LJ, Demedts MG, Verleden GM. Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma. Chest 2003 March;123(3):751-6. (159)Sofia M, Maniscalco M, D'Onofrio G, Carratu P, Vatrilla A. Exhaled nitric oxide as a marker of adverse respiratory health effect in environmental disease. Monaldi Arch Chest Dis 2002 June;57(3-4):182-7. (160)Birrell MA, McCluskie K, Haddad e et al. Pharmacological assessment of the nitric-oxide synthase isoform involved in eosinophilic inflammation in a rat model of sephadex-induced airway inflammation. J Pharmacol Exp Ther 2003 March;304(3):1285-91. (161)Bates CA, Silkoff PE. Exhaled nitric oxide in asthma: from bench to bedside. J Allergy Clin Immunol 2003 February;111(2):256-62. (162)Silkoff P. Exhaled nitric oxide as a diagnostic tool. Am J Respir Crit Care Med 2003 February 15;167(4):665-6. (163)Jang AS, Choi IS, Lee JU. Neuronal nitric oxide synthase is associated with airway obstruction in BALB/c mice exposed to ozone. Respiration 2003 January;70(1):95-9. (164)La Grutta S, Gagliardo R, Mirabella F et al. Clinical and biological heterogeneity in children with moderate asthma. Am J Respir Crit Care Med 2003 June 1;167(11):1490-5. (165)Paredi P, Kharitonov SA, Barnes PJ. Exhaled breath temperature in asthma. Eur Respir J 2003 January;21(1):195. (166)Kharitonov SA, Barnes PJ. Nitric oxide, nitrotyrosine, and nitric oxide modulators in asthma and chronic obstructive pulmonary disease. Curr Allergy Asthma Rep 2003 March;3(2):121-9. (167)Ricciardolo FL. Multiple roles of nitric oxide in the airways. Thorax 2003 February;58(2):175-82. (168)van dL, I, van den Bosch JM, Zanen P. Reduction of variability of exhaled nitric oxide in healthy volunteers. Respir Med 2002 December;96(12):1014-20. (169)Paredi P, Kharitonov SA, Barnes PJ. Analysis of expired air for oxidation products. Am J Respir Crit Care Med 2002 December 15;166(12 Pt 2):S31-S37. (170)Kanazawa H, Hirata K, Yoshikawa J. Nitrogen oxides reduce albuterol-induced bronchodilation in patients with bronchial asthma. Respiration 2002;69(6):490-5. (171)Burgaud JL. Therapeutic strategy for asthma: NO body is perfect. Respiration 2002;69(6):480-1. (172)Fabbri LM, Romagnoli M, Corbetta L et al. Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003 February 1;167(3):418-24. (173)Leme AS, Kasahara DI, Nunes MP, Martins MA, Vieira JE. Exhaled nitric oxide collected with two different mouthpieces: a study in asthmatic patients. Braz J Med Biol Res 2002 October;35(10):1133-7. (174)Lehtimaki L, Kankaanranta H, Saarelainen S, Turjanmaa V, Moilanen E. Increased alveolar nitric oxide concentration in asthmatic patients with nocturnal symptoms. Eur Respir J 2002 October;20(4):841-5. (175)Arruda-Chaves E, De Conti D, Tebaldi T. Nitric oxide sera levels as an inflammatory marker in asthma. J Investig Allergol Clin Immunol 2002;12(2):120-3. (176)Nevin BJ, Broadley KJ. Nitric oxide in respiratory diseases. Pharmacol Ther 2002 September;95(3):259-93. (177)Evsyukova HV. Aspirin-sensitive asthma due to diffuse neuroendocrine system pathology. Neuroendocrinol Lett 2002 August;23(4):281-5. (178)Baraldi E, de Jongste JC. Measurement of exhaled nitric oxide in children, 2001. Eur Respir J 2002 July;20(1):223-37. (179)Wishah K, Malur A, Raychaudhuri B, Melton AL, Kavuru MS, Thomassen MJ. Nitric oxide blocks inflammatory cytokine secretion triggered by CD23 in monocytes from allergic, asthmatic patients and healthy controls. Ann Allergy Asthma Immunol 2002 July;89(1):78-82. (180)Haahtela T. Assessing airway inflammation: from guessing to quantitative measurements. Ann Med 2002;34(2):74-6. (181)Coleman JW. Nitric oxide: a regulator of mast cell activation and mast cell-mediated inflammation. Clin Exp Immunol 2002 July;129(1):4-10. (182)Fischer A, Folkerts G, Geppetti P, Groneberg DA. Mediators of asthma: nitric oxide. Pulm Pharmacol Ther 2002;15(2):73-81. (183)Becker AB. Challenges to treatment goals and outcomes in pediatric asthma. J Allergy Clin Immunol 2002 June;109(6 Suppl):S533-S538. (184)Jang AS, Choi IS, Jeong TK, Lee KY. The effect of cigarette smoking on the levels of nitric oxide metabolites in the sputum of patients with acute asthma. J Asthma 2002 May;39(3):211-6. (185)Kissoon N. Acute asthma: under attack. Curr Opin Pediatr 2002 June;14(3):298-302. (186)Borrish L. Sinusitis and asthma: entering the realm of evidence-based medicine. J Allergy Clin Immunol 2002 April;109(4):606-8. (187)Sade K, Kivity S. Nitric oxide in asthma. Isr Med Assoc J 2002 March;4(3):196-9. (188)Kontogiorgis CA, Hadjipavlou-Litina DJ. Non steroidal anti-inflammatory and anti-allergy agents. Curr Med Chem 2002 January;9(1):89-98. (189)Jacoby DB. Virus-induced asthma attacks. JAMA 2002 February 13;287(6):755-61. (190)Mattes J, Storm Van'S GK, Moeller C, Moseler M, Brandis M, Kuehr J. Circadian variation of exhaled nitric oxide and urinary eosinophil protein X in asthmatic and healthy children. Pediatr Res 2002 February;51(2):190-4. (191)Lipworth BJ. Duration of steroid therapy determines dose-response effect. Chest 2002 January;121(1):306-7. (192)Khatri SB, Ozkan M, McCarthy K et al. Alterations in exhaled gas profile during allergen-induced asthmatic response. Am J Respir Crit Care Med 2001 November 15;164(10 Pt 1):1844-8. (193)Spallarossa D, Battistini E, Silvestri M, Sabatini F, Biraghi MG, Rossi GA. Time-dependent changes in orally exhaled nitric oxide and pulmonary functions induced by inhaled corticosteroids in childhood asthma. J Asthma 2001 October;38(7):545-53. (194)Stick SM. Exhaled nitric oxide in difficult childhood asthma: more light or still chasing shadows? Am J Respir Crit Care Med 2001 October 15;164(8 Pt 1):1335-6. (195)Giroux M, Bremont F, Ferrieres J, Dumas JC. Exhaled NO in asthmatic children in unpolluted and urban environments. Environ Int 2001 October;27(4):335-40. (196)Adnot S, Eddahibi S, Mauran P, Andrivet P, Carville C, Raffestin B. [Nitric oxide, from vascular physiology to therapeutics]. Arch Mal Coeur Vaiss 1994 December;87 Spec No 4:41-51. (197)Alonso C, Proto M, Coviello A, Peral de BM. Insulin improves the endothelium-independent relaxation and the contractile response in aorta from hypertensive diabetic rats. Cell Mol Biol (Noisy -le-grand) 2005 November 8;51(6):565-72. (198)Armstead WM. Role of nitric oxide, cyclic nucleotides, and the activation of ATP-sensitive K+ channels in the contribution of adenosine to hypoxia-induced pial artery dilation. J Cereb Blood Flow Metab 1997 January;17(1):100-8. (199)Arnal JF, Dinh-Xuan AT, Pueyo M, Darblade B, Rami J. Endothelium-derived nitric oxide and vascular physiology and pathology. Cell Mol Life Sci 1999 July;55(8-9):1078-87. (200)Arnal JF, Battle T, Menard J, Michel JB. The vasodilatory effect of endogenous nitric oxide is a major counter-regulatory mechanism in the spontaneously hypertensive rat. J Hypertens 1993 September;11(9):945-50. (201)Boger RH, Bode-Boger SM, Szuba A et al. Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation 1998 November 3;98(18):1842-7. (202)Candipan RC, Wang BY, Buitrago R, Tsao PS, Cooke JP. Regression or progression. Dependency on vascular nitric oxide. Arterioscler Thromb Vasc Biol 1996 January;16(1):44-50. (203)Carey RM, Jin X, Wang Z, Siragy HM. Nitric oxide: a physiological mediator of the type 2 (AT2) angiotensin receptor. Acta Physiol Scand 2000 January;168(1):65-71. (204)Charpie JR, Peters A, Webb RC. A photoactivable source of relaxing factor in genetic hypertension. Hypertension 1994 June;23(6 Pt 2):894-8. (205)Conti CR. Nitric oxide as a therapeutic agent. Clin Cardiol 1994 May;17(5):227-8. (206)Cooke JP, Tsao PS. Go with the flow. Circulation 2001 June 12;103(23):2773-5. (207)Cooke JP. The endothelium: a new target for therapy. Vasc Med 2000;5(1):49-53. (208)Fitzpatrick DF, Bing B, Rohdewald P. Endothelium-dependent vascular effects of Pycnogenol. J Cardiovasc Pharmacol 1998 October;32(4):509-15. (209)Fitzpatrick DF, Bing B, Maggi DA, Fleming RC, O'Malley RM. Vasodilating procyanidins derived from grape seeds. Ann N Y Acad Sci 2002 May;957:78-89. (210)Garcia SR, Bund SJ. Nitric oxide modulation of coronary artery myogenic tone in spontaneously hypertensive and Wistar-Kyoto rats. Clin Sci (Lond) 1998 March;94(3):225-9. (211)Granstam E, Granstam SO, Fellstrom B, Lind L. Endothelium-dependent vasodilation in the uvea of hypertensive and normotensive rats. Curr Eye Res 1998 February;17(2):189-96. (212)Heistad DD, Mayhan WG, Coyle P, Baumbach GL. Impaired dilatation of cerebral arterioles in chronic hypertension. Blood Vessels 1990;27(2-5):258-62. (213)Hirata Y. [NO and hypertension]. Nippon Rinsho 2004 March;62 Suppl 3:243-6. (214)Ito S, Carretero OA. Impaired response to acetylcholine despite intact endothelium-derived relaxing factor/nitric oxide in isolated microperfused afferent arterioles of the spontaneously hypertensive rat. J Cardiovasc Pharmacol 1992;20 Suppl 12:S187-S189. (215)Kagota S, Tamashiro A, Yamaguchi Y et al. Downregulation of vascular soluble guanylate cyclase induced by high salt intake in spontaneously hypertensive rats. Br J Pharmacol 2001 October;134(4):737-44. (216)Kanagy NL, Charpie JR, Webb RC. Nitric oxide regulation of ADP-ribosylation of G proteins in hypertension. Med Hypotheses 1995 March;44(3):159-64. (217)Mathew R, Zeballos GA, Tun H, Gewitz MH. Role of nitric oxide and endothelin-1 in monocrotaline-induced pulmonary hypertension in rats. Cardiovasc Res 1995 November;30(5):739-46. (218)Mattei P, Virdis A, Ghiadoni L, Taddei S, Salvetti A. Endothelial function in hypertension. J Nephrol 1997 July;10(4):192-7. (219)Miyazaki H, Matsuoka H, Cooke JP et al. Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis. Circulation 1999 March 9;99(9):1141-6. (220)Naruse M, Naruse K, Yoshimoto T, Tanaka M, Tanabe A, Demura H. [Clinical significance of nitric oxide in hypertension]. Nippon Naibunpi Gakkai Zasshi 1994 June 20;70(5):489-502. (221)Otsuka Y, DiPiero A, Hirt E, Brennaman B, Lockette W. Vascular relaxation and cGMP in hypertension. Am J Physiol 1988 January;254(1 Pt 2):H163-H169. (222)Pauvert O, Marthan R, Savineau J. NO-induced modulation of calcium-oscillations in pulmonary vascular smooth muscle. Cell Calcium 2000 June;27(6):329-38. (223)Pearse DB, Dahms TE, Wagner EM. Microsphere-induced bronchial artery vasodilation: role of adenosine, prostacyclin, and nitric oxide. Am J Physiol 1998 March;274(3 Pt 2):H760-H768. (224)Puddu P, Puddu GM, Zaca F, Muscari A. Endothelial dysfunction in hypertension. Acta Cardiol 2000 August;55(4):221-32. (225)Ruilope LM, Lahera V, Rodicio JL, Romero JC. Participation of nitric oxide in the regulation of renal function: possible role in the genesis of arterial hypertension. J Hypertens 1994 June;12(6):625-31. (226)Snyder SH. Nitric oxide: first in a new class of neurotransmitters. Science 1992 July 24;257(5069):494-6. (227)Sosa-Canache B, Cierco M, Gutierrez CI, Israel A. Role of bradykinins and nitric oxide in the AT2 receptor-mediated hypotension. J Hum Hypertens 2000 April;14 Suppl 1:S40-S46. (228)Spieker LE, Noll G, Ruschitzka FT, Maier W, Luscher TF. Working under pressure: the vascular endothelium in arterial hypertension. J Hum Hypertens 2000 October;14(10-11):617-30. (229)Taddei S, Virdis A, Ghiadoni L et al. Restoration of nitric oxide availability after calcium antagonist treatment in essential hypertension. Hypertension 2001 March;37(3):943-8. (230)Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A. Cyclooxygenase inhibition restores nitric oxide activity in essential hypertension. Hypertension 1997 January;29(1 Pt 2):274-9. (231)Tawakol A, Forgione MA, Stuehlinger M et al. Homocysteine impairs coronary microvascular dilator function in humans. J Am Coll Cardiol 2002 September 18;40(6):1051-8. (232)Toda N. Nitroxidergic nerves and hypertension. Hypertens Res 1995 March;18(1):19-26. (233)Vallance P. Nitric oxide in human hypertension-up, down or unaffected? Clin Sci (Lond) 1999 September;97(3):343-4. (234)DeFeudis FV, Drieu K. Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications. Curr Drug Targets 2000 July;1(1):25-58. (235)Nathan P. Can the cognitive enhancing effects of ginkgo biloba be explained by its pharmacology? Med Hypotheses 2000 December;55(6):491-3. (236)Dinsmore ST. Treatment options for Alzheimer's disease. J Am Osteopath Assoc 1999 September;99(9 Suppl):S6-S8. (237)Ott BR, Owens NJ. Complementary and alternative medicines for Alzheimer's disease. J Geriatr Psychiatry Neurol 1998;11(4):163-73. (238)Kristofikova Z, Klaschka J. In vitro effect of Ginkgo biloba extract (EGb 761) on the activity of presynaptic cholinergic nerve terminals in rat hippocampus. Dement Geriatr Cogn Disord 1997 January;8(1):43-8. (239)Ramassamy C, Clostre F, Christen Y, Costentin J. Prevention by a Ginkgo biloba extract (GBE 761) of the dopaminergic neurotoxicity of MPTP. J Pharm Pharmacol 1990 November;42(11):785-9. (240)The role of excitatory amino acids in the actions of abused drugs. NIDA Res Monogr 1994;140:65-8. (241)Angel-Meza AR, Ramirez-Cortes L, Adame-Gonzalez IG, Gonzalez B, I, Beas-Zarate C. Cerebral GABA release and GAD activity in protein- and tryptophan- restricted rats during development. Int J Dev Neurosci 2002 February;20(1):47-54. (242)Arrigoni E, Rainnie DG, McCarley RW, Greene RW. Adenosine-mediated presynaptic modulation of glutamatergic transmission in the laterodorsal tegmentum. J Neurosci 2001 February 1;21(3):1076-85. (243)Barbeito L, Cheramy A, Godeheu G, Desce JM, Glowinski J. Glutamate Receptors of a Quisqualate-Kainate Subtype are Involved in the Presynaptic Regulation of Dopamine Release in the Cat Caudate Nucleus in vivo. Eur J Neurosci 1990;2(4):304-11. (244)Belenikin MS, Baskin II, Palyulin VA, Zefirov NS. A new binding mode of competitive antagonists to metabotropic glutamate receptors exemplified by the mGluR1-receptor antagonist AIDA (RS- aminoindan-1,5-dicarboxylic acid). Dokl Biochem Biophys 2002 May;384:131-5. (245)Breysse N, Baunez C, Spooren W, Gasparini F, Amalric M. Chronic but not acute treatment with a metabotropic glutamate 5 receptor antagonist reverses the akinetic deficits in a rat model of parkinsonism. J Neurosci 2002 July 1;22(13):5669-78. (246)Car H, Oksztel R, Nadlewska A, Wisniewski K. NMDA receptor antagonists change behavioral activity of rats treated with (S)-4CPG. Pol J Pharmacol 2001 July;53(4):331-9. (247)Chiang AS, Pszczolkowski MA, Liu HP, Lin SC. Ionotropic glutamate receptors mediate juvenile hormone synthesis in the cockroach, Diploptera punctata. Insect Biochem Mol Biol 2002 June;32(6):669-78. (248)Dhami GK, Anborgh PH, Dale LB, Sterne-Marr R, Ferguson SS. Phosphorylation-independent regulation of metabotropic glutamate receptor signaling by G protein-coupled receptor kinase 2. J Biol Chem 2002 July 12;277(28):25266-72. (249)Diaz-Cabiale Z, Vivo M, del Arco A et al. Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A(2A) and dopamine D(2) receptors. Neurosci Lett 2002 May 17;324(2):154-8. (250)Doi A, Ishibashi H, Jinno S, Kosaka T, Akaike N. Presynaptic inhibition of GABAergic miniature currents by metabotropic glutamate receptor in the rat CNS. (251)Fendt M, Schmid S. Metabotropic glutamate receptors are involved in amygdaloid plasticity. Eur J Neurosci 2002 May;15(9):1535-41. (252)Giuliano F, Rampin O, Allard J. Neurophysiology and pharmacology of female genital sexual response. J Sex Marital Ther 2002;28 Suppl 1:101-21. (253)Grosshans DR, Clayton DA, Coultrap SJ, Browning MD. Analysis of glutamate receptor surface expression in acute hippocampal slices. Sci STKE 2002 June 18;2002(137):L8. (254)Holscher C. Metabotropic glutamate receptors control gating of spike transmission in the hippocampus area CA1. Pharmacol Biochem Behav 2002 September;73(2):307-16. (255)Huemmeke M, Eysel UT, Mittmann T. Metabotropic glutamate receptors mediate expression of LTP in slices of rat visual cortex. Eur J Neurosci 2002 May;15(10):1641-5. (256)Karlsson U, Sjodin J, Angeby MK, Johansson S, Wikstrom L, Nasstrom J. Glutamate-induced currents reveal three functionally distinct NMDA receptor populations in rat dorsal horn - effects of peripheral nerve lesion and inflammation. Neuroscience 2002;112(4):861-8. (257)Katsurabayashi S, Kubota H, Wang ZM, Rhee JS, Akaike N. cAMP-dependent presynaptic regulation of spontaneous glycinergic IPSCs in mechanically dissociated rat spinal cord neurons. J Neurophysiol 2001 January;85(1):332-40. (258)Lee RK, Jimenez J, Cox AJ, Wurtman RJ. Metabotropic glutamate receptors regulate APP processing in hippocampal neurons and cortical astrocytes derived from fetal rats. Ann N Y Acad Sci 1996 January 17;777:338-43. (259)Leinekugel X, Khazipov R, Cannon R, Hirase H, Ben Ari Y, Buzsaki G. Correlated bursts of activity in the neonatal hippocampus in vivo. Science 2002 June 14;296(5575):2049-52. (260)Li W, Trexler EB, Massey SC. Glutamate receptors at rod bipolar ribbon synapses in the rabbit retina. J Comp Neurol 2002 July 1;448(3):230-48. (261)Mao L, Wang JQ. Glutamate Cascade to cAMP Response Element-Binding Protein Phosphorylation in Cultured Striatal Neurons through Calcium-Coupled Group I Metabotropic Glutamate Receptors. Mol Pharmacol 2002 September;62(3):473-84. (262)Martin-Ruiz R, Puig MV, Celada P et al. Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism. J Neurosci 2001 December 15;21(24):9856-66. (263)Meeker RB. Metabotropic and NMDA glutamate receptor interactions with osmotic stimuli in supraoptic neurons. Pharmacol Biochem Behav 2002 September;73(2):475-84. (264)Moghaddam B. Stress activation of glutamate neurotransmission in the prefrontal cortex: implications for dopamine-associated psychiatric disorders. Biol Psychiatry 2002 May 15;51(10):775-87. (265)Neugebauer V. Metabotropic glutamate receptors - important modulators of nociception and pain behavior. Pain 2002 June;98(1-2):1-8. (266)Pisani A, Bonsi P, Catania MV et al. Metabotropic glutamate 2 receptors modulate synaptic inputs and calcium signals in striatal cholinergic interneurons. J Neurosci 2002 July 15;22(14):6176-85. (267)Schoepp DD. Metabotropic glutamate receptors. Pharmacol Biochem Behav 2002 September;73(2):285-6. (268)Sevoz-Couche C, Maisonneuve B, Hamon M, Laguzzi R. Glutamate and NO mediation of the pressor response to 5-HT3 receptor stimulation in the nucleus tractus solitarii. Neuroreport 2002 May 7;13(6):837-41. (269)Suchak SK, Baloyianni NV, Perkinton MS, Williams RJ, Meldrum BS, Rattray M. The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. J Neurochem 2003 February;84(3):522-32. (270)Ulus IH, Wurtman RJ. Metabotropic glutamate receptor agonists increase release of soluble amyloid precursor protein derivatives from rat brain cortical and hippocampal slices. J Pharmacol Exp Ther 1997 April;281(1):149-54. (271)Wang G, Ding S, Yunokuchi K. Glutamate-induced increases in intracellular Ca2+ in cultured rat neocortical neurons. Neuroreport 2002 June 12;13(8):1051-6. (272)Chen JF, Moratalla R, Impagnatiello F et al. The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice. Proc Natl Acad Sci U S A 2001 February 13;98(4):1970-5. (273)Chen JF, Xu K, Petzer JP et al. Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease. J Neurosci 2001 May 15;21(10):RC143. (274)Conlay LA, Conant JA, deBros F, Wurtman R. Caffeine alters plasma adenosine levels. Nature 1997 September 11;389(6647):136. (275)Conlay LA, Evoniuk G, Wurtman RJ. Endogenous adenosine and hemorrhagic shock: effects of caffeine administration or caffeine withdrawal. Proc Natl Acad Sci U S A 1988 June;85(12):4483-5. (276)Dulloo AG, Seydoux J, Girardier L. Potentiation of the thermogenic antiobesity effects of ephedrine by dietary methylxanthines: adenosine antagonism or phosphodiesterase inhibition? Metabolism 1992 November;41(11):1233-41. (277)Dulloo AG, Seydoux J, Girardier L. Peripheral mechanisms of thermogenesis induced by ephedrine and caffeine in brown adipose tissue. Int J Obes 1991 May;15(5):317-26. (278)Dunwiddie TV, Masino SA. The role and regulation of adenosine in the central nervous system. Annu Rev Neurosci 2001;24:31-55. (279)Evoniuk G, von Borstel RW, Wurtman RJ. Antagonism of the cardiovascular effects of adenosine by caffeine or 8- (p-sulfophenyl)theophylline. J Pharmacol Exp Ther 1987 February;240(2):428-32. (280)Schwarzschild MA, Chen JF, Ascherio A. Caffeinated clues and the promise of adenosine A(2A) antagonists in PD. Neurology 2002 April 23;58(8):1154-60. (281)Tofovic SP, Zacharia L, Carcillo JA, Jackson EK. Inhibition of adenosine deaminase attenuates endotoxin-induced release of cytokines in vivo in rats. Shock 2001 September;16(3):196-202. (282)von Borstel RW, Renshaw AA, Wurtman RJ. Adenosine strongly potentiates pressor responses to nicotine in rats. Proc Natl Acad Sci U S A 1984 September;81(17):5599-603. (283)Barcz E, Sommer E, Janik P, Marianowski L, Skopinska-Rozewska E. Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells. Oncol Rep 2000 November;7(6):1285-91. (284)Dulloo AG, Seydoux J, Girardier L. Potentiation of the thermogenic antiobesity effects of ephedrine by dietary methylxanthines: adenosine antagonism or phosphodiesterase inhibition? Metabolism 1992 November;41(11):1233-41. (285)Richter A, Hamann M. Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia. Br J Pharmacol 2001 September;134(2):343-52. (286)Satoh A, Satoh K, Masamune A, Yamagiwa T, Shimosegawa T. Activation of adenosine A2a receptor pathway reduces leukocyte infiltration but enhances edema formation in rat caerulein pancreatitis. Pancreas 2002 January;24(1):75-82. (287)Grosdemouge C, Poncin-Lafitte M, Rapin JR. [Protective effects of Ginkgo biloba extract on the early rupture of the hemato-encephalic barrier in the rat]. Presse Med 1986 September 25;15(31):1502-5. (288)Hodgson JM, Puddey IB, Burke V, Beilin LJ, Jordan N. Effects on blood pressure of drinking green and black tea. J Hypertens 1999 April;17(4):457-63. (289)Liu X, Wei J, Tan F, Zhou S, Wurthwein G, Rohdewald P. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci 2004 January 2;74(7):855-62. (290)Oku H, Ueda Y, Iinuma M, Ishiguro K. Inhibitory effects of xanthones from guttiferae plants on PAF-induced hypotension in mice. Planta Med 2005 January;71(1):90-2. (291)Priyadarshi S, Valentine B, Han C et al. Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat. Kidney Int 2003 May;63(5):1785-90. (292)Yang R, Powell-Braxton L, Ogaoawara AK et al. Hypertension and endothelial dysfunction in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 1999 November;19(11):2762-8. (293)Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord 2000 February;24(2):252-8. (294)Luceri C, Caderni G, Sanna A, Dolara P. Red wine and black tea polyphenols modulate the expression of cycloxygenase-2, inducible nitric oxide synthase and glutathione- related enzymes in azoxymethane-induced f344 rat colon tumors. J Nutr 2002 June;132(6):1376-9. (295)Richelle M, Tavazzi I, Offord E. Comparison of the antioxidant activity of commonly consumed polyphenolic beverages (coffee, cocoa, and tea) prepared per cup serving. J Agric Food Chem 2001 July;49(7):3438-42. (296)Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr 2000 August;130(8S Suppl):2073S-85S. (297)Anghileri LJ, Thouvenot P. Natural polyphenols-iron interaction: its biological importance. Biol Trace Elem Res 2000 March;73(3):251-8. (298)Agnisola C. Role of nitric oxide in the control of coronary resistance in teleosts. Comp Biochem Physiol A Mol Integr Physiol 2005 October;142(2):178-87. (299)Aubert JD. Biochemical markers in the management of pulmonary hypertension. Swiss Med Wkly 2005 January 22;135(3-4):43-9. (300)Bal-Price A, Brown GC. Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J Neurosci 2001 September 1;21(17):6480-91. (301)Buus NH, Bottcher M, Hermansen F, Sander M, Nielsen TT, Mulvany MJ. Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia. Circulation 2001 November 6;104(19):2305-10. (302)Caldarera CM, Muscari C. [Biochemical basis of essential hypertension]. Cardiologia 1989 September;34(9):741-9. (303)Champion HC, Bivalacqua TJ, Greenberg SS, Giles TD, Hyman AL, Kadowitz PJ. Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice. Proc Natl Acad Sci U S A 2002 October 1;99(20):13248-53. (304)Fineman JR, Heymann MA, Soifer SJ. N omega-nitro-L-arginine attenuates endothelium-dependent pulmonary vasodilation in lambs. Am J Physiol 1991 April;260(4 Pt 2):H1299-H1306. (305)Finnerty FA, Jr. Hypertensive crisis. JAMA 1974 September 9;229(11):1479-80. (306)Cadwgan TM, Benjamin N. Evidence for altered platelet nitric oxide synthesis in essential hypertension. J Hypertens 1993 April;11(4):417-20. (307)Camilletti A, Moretti N, Giacchetti G et al. Decreased nitric oxide levels and increased calcium content in platelets of hypertensive patients. Am J Hypertens 2001 April;14(4 Pt 1):382-6. (308)Chabielska E, Pawlak R, Wollny T, Rolkowski R, Buczko W. Antithrombotic activity of losartan in two kidney, one clip hypertensive rats. A study on the mechanism of action. J Physiol Pharmacol 1999 March;50(1):99-109. (309)Li Y, Adachi T, Bolotina VM, Knowles C, Ault KA, Cohen RA. Abnormal platelet function and calcium handling in Dahl salt-hypertensive rats. Hypertension 2001 April;37(4):1129-35. (310)Luscher TF. [Hypertension and vascular diseases: molecular and cellular mechanisms]. Schweiz Med Wochenschr 1995 February 18;125(7):270-82. (311)Luscher TF, Vanhoutte PM. Endothelium-dependent responses to platelets and serotonin in spontaneously hypertensive rats. Hypertension 1986 June;8(6 Pt 2):II55-II60. (312)Minamino T, Kitakaze M, Sato H et al. Plasma levels of nitrite/nitrate and platelet cGMP levels are decreased in patients with atrial fibrillation. Arterioscler Thromb Vasc Biol 1997 November;17(11):3191-5. (313)Moss MB, Brunini TM, Soares De MR et al. Diminished L-arginine bioavailability in hypertension. Clin Sci (Lond) 2004 October;107(4):391-7. (314)Naseem KM. The role of nitric oxide in cardiovascular diseases. Mol Aspects Med 2005 February;26(1-2):33-65. (315)Pernollet MG, Kunes J, Zicha J, Devynck MA. Cyclic nucleotides in platelets of genetically hypertriglyceridemic and hypertensive rats. Thrombin and nitric oxide responses are unrelated to plasma triglyceride levels. Thromb Res 2001 October 1;104(1):29-37. (316)Raij L. Hypertension, endothelium, and cardiovascular risk factors. Am J Med 1991 February 21;90(2A):13S-8S. (317)Santiago M, Reis F, Almeida L, Alcobia T, Dionisio J, Teixeira F. Impairment of vascular and platelet levels of nitric oxide and cyclic guanosine-3',5'-monophosphate in cyclosporin A-induced hypertensive rats. Fundam Clin Pharmacol 2003 February;17(1):43-50. (318)Vanhoutte PM. Serotonin, hypertension and vascular disease. Neth J Med 1991 February;38(1-2):35-42. (319)Vasdev S, Ford CA, Longerich L, Parai S, Gadag V, Wadhawan S. Aldehyde induced hypertension in rats: prevention by N-acetyl cysteine. Artery 1998;23(1):10-36. (320)Ware JA, Heistad DD. Seminars in medicine of the Beth Israel Hospital, Boston. Platelet-endothelium interactions. N Engl J Med 1993 March 4;328(9):628-35. (321)Woods JD, Edwards JS, Ritter JM. Inhibition by nitroprusside of platelet calcium mobilization: evidence for reduced sensitivity to nitric oxide in essential hypertension. J Hypertens 1993 December;11(12):1369-73. (322)Zozulia OV, Rogov VA, Belushkina NN, Riaposova IK, Beilin AL, Dzgoeva FU. [The preliminary results of a study of the role of endogenous nitric oxide in pregnant women with chronic glomerulonephritis, hypertension and puerperal eclampsia]. Urol Nefrol (Mosk) 1995 September;(5):23-5. (323)Bernatova I, Pechanova O, Babal P, Kysela S, Stvrtina S, Andriantsitohaina R. Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension. Am J Physiol Heart Circ Physiol 2002 March;282(3):H942-H948. (324)Boer J, Duyvendak M, Schuurman FE, Pouw FM, Zaagsma J, Meurs H. Role of L-arginine in the deficiency of nitric oxide and airway hyperreactivity after the allergen-induced early asthmatic reaction in guinea-pigs. Br J Pharmacol 1999 November;128(5):1114-20. (325)Bourraindeloup M, Adamy C, Candiani G et al. N-acetylcysteine treatment normalizes serum tumor necrosis factor-alpha level and hinders the progression of cardiac injury in hypertensive rats. Circulation 2004 October 5;110(14):2003-9. (326)de Gracia MC, Osuna A, O'Valle F et al. Deoxycorticosterone suppresses the effects of losartan in nitric oxide-deficient hypertensive rats. J Am Soc Nephrol 2000 November;11(11):1995-2000. (327)Dobesova Z, Kunes J, Zicha J. The altered balance between sympathetic nervous system and nitric oxide in salt hypertensive Dahl rats: ontogenetic and F2 hybrid studies. J Hypertens 2002 May;20(5):945-55. (328)Fakler CR, Kaftan HA, Nelin LD. Two cases suggesting a role for the L-arginine nitric oxide pathway in neonatal blood pressure regulation. Acta Paediatr 1995 April;84(4):460-2. (329)Jang JJ, Ho HK, Kwan HH, Fajardo LF, Cooke JP. Angiogenesis is impaired by hypercholesterolemia: role of asymmetric dimethylarginine. Circulation 2000 September 19;102(12):1414-9. (330)Morris CR, Morris SM, Jr., Hagar W et al. Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease? Am J Respir Crit Care Med 2003 July 1;168(1):63-9. (331)Ohtani K, Egashira K. [NO and atherosclerosis]. Nippon Rinsho 2004 September;62 Suppl 9:544-7. (332)Cooke JP, Tsao PS. Arginine: a new therapy for atherosclerosis? Circulation 1997 January 21;95(2):311-2. (333)Cooke JP. Nutriceuticals for cardiovascular health. Am J Cardiol 1998 November 19;82(10A):43S-6S. (334)Cooke JP, Tsao PS. Arginine: a new therapy for atherosclerosis? Circulation 1997 January 21;95(2):311-2. (335)Cooke JP, Singer AH, Tsao P, Zera P, Rowan RA, Billingham ME. Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. J Clin Invest 1992 September;90(3):1168-72. (336)Cooke JP, Dzau J, Creager A. Endothelial dysfunction in hypercholesterolemia is corrected by L-arginine. Basic Res Cardiol 1991;86 Suppl 2:173-81. (337)Cornfield DN, Martin EB, Hampl V, Archer SL. Aerosol delivery of diethylenetriamine/nitric oxide, a nitric oxide adduct, causes selective pulmonary vasodilation in perinatal lambs. J Lab Clin Med 1999 October;134(4):419-25. (338)Endoh M, Odamaki M, Ikegaya N, Kumagai H. Factors involved in the development of hypertension induced by a low-protein diet in rats with renal injury. Kidney Blood Press Res 2004;27(1):1-9. (339)Fernandez-Rivas A, Garcia-Estan J, Vargas F. Effects of chronic increased salt intake on nitric oxide synthesis inhibition-induced hypertension. J Hypertens 1995 January;13(1):123-8. (340)Higashi Y, Oshima T, Watanabe M, Matsuura H, Kajiyama G. Renal response to L-arginine in salt-sensitive patients with essential hypertension. Hypertension 1996 March;27(3 Pt 2):643-8. (341)Jolma P, Kalliovalkama J, Tolvanen JP et al. High-calcium diet enhances vasorelaxation in nitric oxide-deficient hypertension. Am J Physiol Heart Circ Physiol 2000 September;279(3):H1036-H1043. (342)Kataoka H, Otsuka F, Ogura T et al. The role of nitric oxide and the renin-angiotensin system in salt-restricted Dahl rats. Am J Hypertens 2001 March;14(3):276-85. (343)Kawamoto E, Sakai Y, Okamura Y, Yamamoto Y. Effects of boiling on the antihypertensive and antioxidant activities of onion. J Nutr Sci Vitaminol (Tokyo) 2004 June;50(3):171-6. (344)Kawano T, Nomura M, Nisikado A, Nakaya Y, Ito S. Supplementation of L-arginine improves hypertension and lipid metabolism but not insulin resistance in diabetic rats. Life Sci 2003 October 24;73(23):3017-26. (345)Kelly BS, Alexander JW, Dreyer D et al. Oral arginine improves blood pressure in renal transplant and hemodialysis patients. JPEN J Parenter Enteral Nutr 2001 July;25(4):194-202. (346)Lin KY, Ito A, Asagami T et al. Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation 2002 August 20;106(8):987-92. (347)Maxwell AJ, Anderson B, Zapien MP, Cooke JP. Endothelial dysfunction in hypercholesterolemia is reversed by a nutritional product designed to enhance nitric oxide activity. Cardiovasc Drugs Ther 2000 June;14(3):309-16. (348)Muroyama K, Murosaki S, Yamamoto Y, Ishijima A, Toh Y. Effects of intake of a mixture of thiamin, arginine, caffeine, and citric acid on adiposity in healthy subjects with high percent body fat. Biosci Biotechnol Biochem 2003 November;67(11):2325-33. (349)Ni Z, Oveisi F, Vaziri ND. Nitric oxide synthase isotype expression in salt-sensitive and salt-resistant Dahl rats. Hypertension 1999 October;34(4 Pt 1):552-7. (350)Rasmusen C, Cynober L, Couderc R. [Arginine and statins: relationship between the nitric oxide pathway and the atherosclerosis development]. Ann Biol Clin (Paris) 2005 September;63(5):443-55. (351)Vosatka RJ, Hassoun PM, Harvey-Wilkes KB. Dietary L-arginine prevents fetal growth restriction in rats. Am J Obstet Gynecol 1998 February;178(2):242-6. (352)Wang BY, Ho HK, Lin PS et al. Regression of atherosclerosis: role of nitric oxide and apoptosis. Circulation 1999 March 9;99(9):1236-41. (353)Wolf A, Zalpour C, Theilmeier G et al. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol 1997 March 1;29(3):479-85. (354)Yamada SS, Sassaki AL, Fujihara CK, Malheiros DM, De NG, Zatz R. Effect of salt intake and inhibitor dose on arterial hypertension and renal injury induced by chronic nitric oxide blockade. Hypertension 1996 May;27(5):1165-72. (355)Yokozawa T, Cho EJ, Nakagawa T. Influence of green tea polyphenol in rats with arginine-induced renal failure. J Agric Food Chem 2003 April 9;51(8):2421-5. (356)Abbasi F, Asagmi T, Cooke JP et al. Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus. Am J Cardiol 2001 November 15;88(10):1201-3. (357)Abbasi F, Asagmi T, Cooke JP et al. Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus. Am J Cardiol 2001 November 15;88(10):1201-3. (358)Boger RH, Bode-Boger SM, Szuba A et al. Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation 1998 November 3;98(18):1842-7. (359)Carlin School, Franz KB. Magnesium deficiency during pregnancy in rats increases systolic blood pressure and plasma nitrite. Am J Hypertens 2002 December;15(12):1081-6. (360)Chan JR, Boger RH, Bode-Boger SM et al. Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans. Arterioscler Thromb Vasc Biol 2000 April;20(4):1040-6. (361)Cooke JP. Does ADMA cause endothelial dysfunction? Arterioscler Thromb Vasc Biol 2000 September;20(9):2032-7. (362)Edwards DL, Arora CP, Bui DT, Castro LC. Long-term nitric oxide blockade in the pregnant rat: effects on blood pressure and plasma levels of endothelin-1. Am J Obstet Gynecol 1996 August;175(2):484-8. (363)Fickling SA, Williams D, Vallance P, Nussey SS, Whitley GS. Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and pre-eclampsia. Lancet 1993 July 24;342(8865):242-3. (364)Fujiwara N, Osanai T, Kamada T, Katoh T, Takahashi K, Okumura K. Study on the relationship between plasma nitrite and nitrate level and salt sensitivity in human hypertension : modulation of nitric oxide synthesis by salt intake. Circulation 2000 February 29;101(8):856-61. (365)Garcia VM, Ochoa JE, Elias MM. Effect of early stage of experimental diabetes on vascular functions in isolated perfused kidneys. J Auton Pharmacol 1999 April;19(2):97-103. (366)Garlichs CD, Beyer J, Zhang H et al. Decreased plasma concentrations of L-hydroxy-arginine as a marker of reduced NO formation in patients with combined cardiovascular risk factors. J Lab Clin Med 2000 May;135(5):419-25. (367)Gorenflo M, Zheng C, Werle E, Fiehn W, Ulmer HE. Plasma levels of asymmetrical dimethyl-L-arginine in patients with congenital heart disease and pulmonary hypertension. J Cardiovasc Pharmacol 2001 April;37(4):489-92. (368)Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999 June 22;99(24):3092-5. (369)Jang JJ, Ho HK, Kwan HH, Fajardo LF, Cooke JP. Angiogenesis is impaired by hypercholesterolemia: role of asymmetric dimethylarginine. Circulation 2000 September 19;102(12):1414-9. (370)Kavvadia V, Greenough A, Lilley J et al. Plasma arginine levels and the response to inhaled nitric oxide in neonates. Biol Neonate 1999 December;76(6):340-7. (371)Lin KY, Ito A, Asagami T et al. Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation 2002 August 20;106(8):987-92. (372)Lundman P, Eriksson MJ, Stuhlinger M, Cooke JP, Hamsten A, Tornvall P. Mild-to-moderate hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentrations of asymmetric dimethylarginine. J Am Coll Cardiol 2001 July;38(1):111-6. (373)Maejima K, Himeno M, Ishibashi T, Nakano S, Nishio M, Uchida K. Paradoxical decrease in plasma NOx by L-arginine load in diabetic and non-diabetic subjects. Clin Exp Hypertens 2002 April;24(3):155-67. (374)Miyazaki H, Matsuoka H, Cooke JP et al. Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis. Circulation 1999 March 9;99(9):1141-6. (375)Stuhlinger MC, Abbasi F, Chu JW et al. Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor. JAMA 2002 March 20;287(11):1420-6. (376)Stuhlinger MC, Tsao PS, Her JH, Kimoto M, Balint RF, Cooke JP. Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation 2001 November 20;104(21):2569-75. (377)Sugimoto K, Tsuruoka S, Fujimura A. Effect of prolonged nitric oxide synthesis inhibition on plasma fibrinogen concentration in rats. Jpn J Pharmacol 2001 January;85(1):114-6. (378)Surdacki A, Nowicki M, Sandmann J et al. Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension. J Cardiovasc Pharmacol 1999 April;33(4):652-8. (379)Tangphao O, Chalon S, Coulston AM et al. L-arginine and nitric oxide-related compounds in plasma: comparison of normal and arginine-free diets in a 24-h crossover study. Vasc Med 1999;4(1):27-32. (380)Tong YC, Wang CJ, Cheng JT. The role of nitric oxide in the control of plasma glucose concentration in spontaneously hypertensive rats. Neurosci Lett 1997 September 19;233(2-3):93-6. (381)Tsao PS, Theilmeier G, Singer AH, Leung LL, Cooke JP. L-arginine attenuates platelet reactivity in hypercholesterolemic rabbits. Arterioscler Thromb 1994 October;14(10):1529-33. (382)Wang BY, Singer AH, Tsao PS, Drexler H, Kosek J, Cooke JP. Dietary arginine prevents atherogenesis in the coronary artery of the hypercholesterolemic rabbit. J Am Coll Cardiol 1994 February;23(2):452-8. (383)Wolf A, Zalpour C, Theilmeier G et al. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol 1997 March 1;29(3):479-85. (384)Wu CC, Yen MH. Higher level of plasma nitric oxide in spontaneously hypertensive rats. Am J Hypertens 1999 May;12(5):476-82. (385)Baraldi E, Zanconato S. The labyrinth of asthma phenotypes and exhaled NO. Thorax 2001 May;56(5):333-5. (386)Hansel TT, Kharitonov SA, Donnelly LE et al. A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics. FASEB J 2003 July;17(10):1298-300. (387)Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne EA, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994 January 15;343(8890):133-5. (388)Sapienza MA, Kharitonov SA, Horvath I, Chung KF, Barnes PJ. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998 March;53(3):172-5. (389)Yates DH, Kharitonov SA, Robbins RA, Thomas PS, Barnes PJ. Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide. Am J Respir Crit Care Med 1995 September;152(3):892-6. (390)Al-Nimri MA, Komers R, Oyama TT, Subramanya AR, Lindsley JN, Anderson S. Endothelial-derived vasoactive mediators in polycystic kidney disease. Kidney Int 2003 May;63(5):1776-84. (391)Altug S, Demiryurek AT, Cakici I, Kanzik I. The beneficial effects of peroxynitrite on ischaemia-reperfusion arrhythmias in rat isolated hearts. Eur J Pharmacol 1999 November 19;384(2-3):157-62. (392)El-Remessy AB, Behzadian MA, bou-Mohamed G, Franklin T, Caldwell RW, Caldwell RB. Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor. Am J Pathol 2003 June;162(6):1995-2004. (393)Gross A, Dugas N, Spiesser S et al. Nitric oxide production in human macrophagic cells phagocytizing opsonized zymosan: direct characterization by measurement of the luminol dependent chemiluminescence. Free Radic Res 1998 February;28(2):179-91. (394)Higashi Y, Oshima T, Sasaki S et al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension 1998 July;32(1):16-24. (395)Kelly JJ, Tam SH, Williamson PM, Lawson J, Whitworth JA. The nitric oxide system and cortisol-induced hypertension in humans. Clin Exp Pharmacol Physiol 1998 November;25(11):945-6. (396)Kobayashi T, Kamata K. Effect of chronic insulin treatment on NO production and endothelium-dependent relaxation in aortae from established STZ-induced diabetic rats. Atherosclerosis 2001 April;155(2):313-20. (397)Ni Z, Bemanian S, Kivlighn SD, Vaziri ND. Role of endothelin and nitric oxide imbalance in the pathogenesis of hypoxia-induced arterial hypertension. Kidney Int 1998 July;54(1):188-92. (398)Niebauer J, Clark AL, Webb-Peploe KM, Boger R, Coats AJ. Home-based exercise training modulates pro-oxidant substrates in patients with chronic heart failure. Eur J Heart Fail 2005 March 2;7(2):183-8. (399)Ogasa T, Nakano H, Ide H et al. Flow-mediated release of nitric oxide in isolated, perfused rabbit lungs. J Appl Physiol 2001 July;91(1):363-70. (400)Zhou MS, Kosaka H, Yoneyama H. Potassium augments vascular relaxation mediated by nitric oxide in the carotid arteries of hypertensive Dahl rats. Am J Hypertens 2000 June;13(6 Pt 1):666-72. (401)Artinian LR, Ding JM, Gillette MU. Carbon monoxide and nitric oxide: interacting messengers in muscarinic signaling to the brain's circadian clock. Exp Neurol 2001 October;171(2):293-300. (402)Borgonio A, Witte K, Stahrenberg R, Lemmer B. Influence of circadian time, ageing, and hypertension on the urinary excretion of nitric oxide metabolites in rats. Mech Ageing Dev 1999 November 2;111(1):23-37. (403)Higashi Y, Nakagawa K, Kimura M et al. Circadian variation of blood pressure and endothelial function in patients with essential hypertension:a comparison of dippers and non-dippers. J Am Coll Cardiol 2002 December 4;40(11):2039-43. (404)Mizutani K, Ikeda K, Tsuda K, Yamori Y. Inhibitor for advanced glycation end products formation attenuates hypertension and oxidative damage in genetic hypertensive rats. J Hypertens 2002 August;20(8):1607-14. (405)Falciani M, Rinaldi B, D'Agostino B et al. Effects of nebivolol on human platelet aggregation. J Cardiovasc Pharmacol 2001 December;38(6):922-9. (406)Ferreira MA, Nunes OD, Fujimura AH, Pessoa OD, Lemos TL, Viana GS. Inhibition of platelet activation by quinones isolated from Auxemma oncocalyx Taub. Res Commun Mol Pathol Pharmacol 1999;106(1-2):97-107. (407)McKendrick JD, Salas E, Dube GP, Murat J, Russell JC, Radomski MW. Inhibition of nitric oxide generation unmasks vascular dysfunction in insulin-resistant, obese JCR:LA-cp rats. Br J Pharmacol 1998 May;124(2):361-9. (408)Riddell DR, Graham A, Owen JS. Apolipoprotein E inhibits platelet aggregation through the L-arginine:nitric oxide pathway. Implications for vascular disease. J Biol Chem 1997 January 3;272(1):89-95. (409)Sabetkar M, Naseem KM, Tullett JM, Friebe A, Koesling D, Bruckdorfer KR. Synergism between nitric oxide and hydrogen peroxide in the inhibition of platelet function: the roles of soluble guanylyl cyclase and vasodilator-stimulated phosphoprotein. Nitric Oxide 2001 June;5(3):233-42. (410)Trovati M, Massucco P, Mattiello L et al. The insulin-induced increase of guanosine-3',5'-cyclic monophosphate in human platelets is mediated by nitric oxide. Diabetes 1996 June;45(6):768-70. (411)Trovati M, Massucco P, Mattiello L, Mularoni E, Cavalot F, Anfossi G. Insulin increases guanosine-3',5'-cyclic monophosphate in human platelets. A mechanism involved in the insulin anti-aggregating effect. Diabetes 1994 August;43(8):1015-9. (412)Aikio O, Vuopala K, Pokela ML, Andersson S, Hallman M. Nitrotyrosine and NO synthases in infants with respiratory failure: Influence of inhaled NO. Pediatr Pulmonol 2003 January;35(1):8-16. (413)Heinonen E, Merilainen P, Hogman M. Administration of nitric oxide into open lung regions: delivery and monitoring. Br J Anaesth 2003 March;90(3):338-42. (414)Lee ML, Chiu IS. Inhaled nitric oxide for persistent pulmonary hypertension in a neonate with pulmonary atresia and intact ventricular septum after radiofrequency valvulotomy, balloon valvuloplasty and Blalock-Taussig shunt. Int J Cardiol 2003 February;87(2-3):273-7. (415)Adatia I. Recent advances in pulmonary vascular disease. Curr Opin Pediatr 2002 June;14(3):292-7. (416)Atz AM, Lefler AK, Fairbrother DL, Uber WE, Bradley SM. Sildenafil augments the effect of inhaled nitric oxide for postoperative pulmonary hypertensive crises. J Thorac Cardiovasc Surg 2002 September;124(3):628-9. (417)Castelain V, Chemla D, Humbert M et al. Pulmonary artery pressure-flow relations after prostacyclin in primary pulmonary hypertension. Am J Respir Crit Care Med 2002 February 1;165(3):338-40. (418)Clini E, Ambrosino N. Nitric oxide and pulmonary circulation. Med Sci Monit 2002 August;8(8):RA178-RA182. (419)Conrad SA, Bidani A. Management of the acute respiratory distress syndrome. Chest Surg Clin N Am 2002 May;12(2):325-54. (420)Dweik RA. Pulmonary hypertension and the search for the selective pulmonary vasodilator. Lancet 2002 September 21;360(9337):886-7. (421)Galie N, Manes A, Branzi A. Emerging medical therapies for pulmonary arterial hypertension. Prog Cardiovasc Dis 2002 November;45(3):213-24. (422)Geary C, Whitsett J. Inhaled nitric oxide for oligohydramnios-induced pulmonary hypoplasia: a report of two cases and review of the literature. J Perinatol 2002 January;22(1):82-5. (423)Ghofrani HA, Wiedemann R, Rose F et al. Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension. Ann Intern Med 2002 April 2;136(7):515-22. (424)Gianetti J, Bevilacqua S, De Caterina R. Inhaled nitric oxide: more than a selective pulmonary vasodilator. Eur J Clin Invest 2002 August;32(8):628-35. (425)Gillies HC, Roblin D, Jackson G. Coronary and systemic hemodynamic effects of sildenafil citrate: from basic science to clinical studies in patients with cardiovascular disease. Int J Cardiol 2002 December;86(2-3):131-41. (426)Haas KM, Suzuki S, Yamaguchi N et al. Nitric oxide further attenuates pulmonary hypertension in magnesium-treated piglets. Pediatr Int 2002 December;44(6):670-4. (427)Hoeper MM, Galie N, Simonneau G, Rubin LJ. New treatments for pulmonary arterial hypertension. Am J Respir Crit Care Med 2002 May 1;165(9):1209-16. (428)Hurford WE. Inhaled nitric oxide. Respir Care Clin N Am 2002 June;8(2):261-79. (429)Kemming G, Habler O, Kleen M, Kisch-Wedel H, Welte M, Zwissler B. Searching the ideal inhaled vasodilator: from nitric oxide to prostacyclin. Eur Surg Res 2002 January;34(1-2):196-202. (430)Lowson SM. Inhaled alternatives to nitric oxide. Anesthesiology 2002 June;96(6):1504-13. (431)Mosquera I, Crespo-Leiro MG, Tabuyo T et al. Pulmonary hypertension and right ventricular failure after heart transplantation: usefulness of nitric oxide. Transplant Proc 2002 February;34(1):166-7. (432)Neunteufl T, Berger R, Pacher R. Endothelin receptor antagonists in cardiology clinical trials. Expert Opin Investig Drugs 2002 March;11(3):431-43. (433)Sanchez O, Humbert M, Sitbon O, Nunes H, Garcia G, Simonneau G. [Pulmonary hypertension associated with connective tissue diseases]. Rev Med Interne 2002 January;23(1):41-54. (434)Sanchez O, Nunes H, Sitbon O, Garcia G, Simonneau G, Humbert M. [Pulmonary hypertension associated with systemic sclerosis]. Ann Med Interne (Paris) 2002 June;153(4):250-9. (435)Sitbon O, Humbert M, Simonneau G. Primary pulmonary hypertension: Current therapy. Prog Cardiovasc Dis 2002 September;45(2):115-28. (436)Su BH, Lin TW, Lin HC, Tsai FJ, Peng CT. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn: four-year experience in a single medical center. Acta Paediatr Taiwan 2002 September;43(5):259-64. (437)Ware LE. Inhaled nitric oxide in infants and children. Crit Care Nurs Clin North Am 2002 March;14(1):1-6. (438)Braschi A, Iannuzzi M, Belliato M, Iotti GA. Therapeutic use of nitric oxide in critical settings. Monaldi Arch Chest Dis 2001 April;56(2):177-9. (439)Channick RN, Rubin LJ. New and experimental therapies for pulmonary hypertension. Clin Chest Med 2001 September;22(3):539-45. (440)Cracowski JL, Cracowski C, Bessard G et al. Increased lipid peroxidation in patients with pulmonary hypertension. Am J Respir Crit Care Med 2001 September 15;164(6):1038-42. (441)Cremona G. Nitric oxide and control of pulmonary vascular resistance. Monaldi Arch Chest Dis 2001 April;56(2):158-64. (442)De Backer TL, Smedema JP, Carlier SG. Current management of primary pulmonary hypertension. BioDrugs 2001;15(12):801-17. (443)Gladwin MT, Schechter AN. Nitric oxide therapy in sickle cell disease. Semin Hematol 2001 October;38(4):333-42. (444)Hayward CS, Macdonald PS, Keogh AM. Inhaled nitric oxide in cardiology. Expert Opin Investig Drugs 2001 November;10(11):1947-56. (445)McMahon CJ, Kadkin J, Nihill MR. Rapid regression of primary pulmonary hypertension. Heart 2001 July;86(1):E1. (446)Naeije R, Barbera JA. Pulmonary hypertension associated with COPD. Crit Care 2001 December;5(6):286-9. (447)Robbins IM, Barst RJ, Channick RN, Rubin LJ. Pulmonary vasoreactivity in PPH. J Am Coll Cardiol 2001 October;38(4):1267-8. (448)Saidy K, al Alaiyan S. The use of L-arginine [correction of F-arginine] and phosphodiesterase inhibitor (dipyridamole) to wean from inhaled nitric oxide. Indian J Pediatr 2001 February;68(2):175-7. (449)Zhao L, Mason NA, Morrell NW et al. Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation 2001 July 24;104(4):424-8. (450)Ashutosh K, Phadke K, Jackson JF, Steele D. Use of nitric oxide inhalation in chronic obstructive pulmonary disease. Thorax 2000 February;55(2):109-13. (451)Bigatello LM. Nitric oxide: modulation of the pulmonary circulation. Minerva Anestesiol 2000 May;66(5):307-13. (452)Ferlito S. Cardiovascular diseases and nitric oxide in humans. Minerva Cardioangiol 2000 November;48(11):379-86. (453)Fike CD, Kaplowitz MR, Rehorst-Paea LA, Nelin LD. L-Arginine increases nitric oxide production in isolated lungs of chronically hypoxic newborn pigs. J Appl Physiol 2000 May;88(5):1797-803. (454)Hampl V, Herget J. Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension. Physiol Rev 2000 October;80(4):1337-72. (455)Redding JS, Cooke JE. Management of pulmonary edema. AORN J 1975 March;21(4):659-60, 662, 664. (456)Redding JS, Cooke JE. Management of pulmonary edema. AORN J 1975 March;21(4):659-60, 662, 664. (457)Abe Y, Itoh K, Arakawa Y. Altered vascular response to acetylcholine in conditions of endothelial damage in the isolated perfused rat stomach. J Gastroenterol 2000;35(2):93-8. (458)Abeywardena MY, Head RJ. Dietary polyunsaturated fatty acid and antioxidant modulation of vascular dysfunction in the spontaneously hypertensive rat. Prostaglandins Leukot Essent Fatty Acids 2001 August;65(2):91-7. (459)Abou-Mohamed G, Kaesemeyer WH, Caldwell RB, Caldwell RW. Role of L-arginine in the vascular actions and development of tolerance to nitroglycerin. Br J Pharmacol 2000 May;130(2):211-8. (460)Alabadi JA, Miranda FJ, Llorens S, Ruiz de Apodaca RF, Centeno JM, Alborch E. Diabetes potentiates acetylcholine-induced relaxation in rabbit renal arteries. Eur J Pharmacol 2001 March;415(2-3):225-32. (461)Ammar RF, Jr., Gutterman DD, Brooks LA, Dellsperger KC. Free radicals mediate endothelial dysfunction of coronary arterioles in diabetes. Cardiovasc Res 2000 August 18;47(3):595-601. (462)Andrawis N, Jones DS, Abernethy DR. Aging is associated with endothelial dysfunction in the human forearm vasculature. J Am Geriatr Soc 2000 February;48(2):193-8. (463)Andrews NP, Husain M, Dakak N, Quyyumi AA. Platelet inhibitory effect of nitric oxide in the human coronary circulation: impact of endothelial dysfunction. J Am Coll Cardiol 2001 February;37(2):510-6. (464)Arimura K, Egashira K, Nakamura R et al. Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure. Am J Physiol Heart Circ Physiol 2001 January;280(1):H68-H75. (465)Baron AD. Insulin resistance and vascular function. J Diabetes Complications 2002 January;16(1):92-102. (466)Barton M, Glodny B. Endothelin receptor blockade and nitric oxide bioactivity. Cardiovasc Res 2001 October;52(1):161-3. (467)Bassenge E. [Modulation of coronary tone: the role of the endothelium]. G Ital Cardiol 1990 November;20(11):1062-9. (468)Benito S, Lopez D, Saiz MP et al. A flavonoid-rich diet increases nitric oxide production in rat aorta. Br J Pharmacol 2002 February;135(4):910-6. (469)Busse R, Edwards G, Feletou M, Fleming I, Vanhoutte PM, Weston AH. EDHF: bringing the concepts together. Trends Pharmacol Sci 2002 August;23(8):374-80. (470)Calles-Escandon J, Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev 2001 February;22(1):36-52. (471)Cooke JP. The endothelium: a new target for therapy. Vasc Med 2000;5(1):49-53. (472)de Belder AJ, Radomski MW. Nitric oxide in the clinical arena. J Hypertens 1994 June;12(6):617-24. (473)de la SA. Vascular abnormalities in salt-sensitive hypertension. Curr Hypertens Rep 2003 April;5(2):93-4. (474)Dominiczak AF, Bohr DF. Nitric oxide and hypertension in 1995. Curr Opin Nephrol Hypertens 1996 March;5(2):174-80. (475)Ferro CJ, Webb DJ. Endothelial dysfunction and hypertension. Drugs 1997;53 Suppl 1:30-41. (476)Fields CE, Makhoul RG. Vasomotor tone and the role of nitric oxide. Semin Vasc Surg 1998 September;11(3):181-92. (477)Galley HF, Webster NR. Physiology of the endothelium. Br J Anaesth 2004 July;93(1):105-13. (478)Hernandez HR, Carvajal AR, rmas de Hernandez MJ, rmas Padilla MC. [Platelet aggregation in arterial hypertension]. Invest Clin 1997 November;38 Suppl 2:41-6. (479)Herrmann J, Lerman A. The endothelium: dysfunction and beyond. J Nucl Cardiol 2001 March;8(2):197-206. (480)Hirata Y. [Role of NO in essential hypertension]. Nippon Rinsho 2004 September;62 Suppl 9:518-21. (481)Hornig B, Drexler H. Endothelial function and bradykinin in humans. Drugs 1997;54 Suppl 5:42-7. (482)Iaccarino G, Ciccarelli M, Sorriento D et al. AKT participates in endothelial dysfunction in hypertension. Circulation 2004 June 1;109(21):2587-93. (483)Katakam PV, Ujhelyi MR, Hoenig M, Miller AW. Metformin improves vascular function in insulin-resistant rats. Hypertension 2000 January;35(1 Pt 1):108-12. (484)Kiowski W. Endothelial dysfunction in hypertension. Clin Exp Hypertens 1999 July;21(5-6):635-46. (485)Marin J, Rodriguez-Martinez MA. Role of vascular nitric oxide in physiological and pathological conditions. Pharmacol Ther 1997 August;75(2):111-34. (486)Himmel W, Lonker B, Kochen MM. [Relevance of general practitioner's prescriptions for hospital pharmacotherapy. A survey of hospital physicians]. Dtsch Med Wochenschr 1996 November 22;121(47):1451-6. (487)Hodgson JM, Burke V, Puddey IB. Acute effects of tea on fasting and postprandial vascular function and blood pressure in humans. J Hypertens 2005 January;23(1):47-54. (488)Kupnovyts'ka MI, Lushchyk UB, Herasymchuk RD, Chmyr HS, Iatsyshyn RI, Dubanovych LB. [A new approach to the treatment of patients with circulatory encephalopathy]. Lik Sprava 1997 September;(5):142-5. (489)Negishi H, Xu JW, Ikeda K, Njelekela M, Nara Y, Yamori Y. Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats. J Nutr 2004 January;134(1):38-42. (490)Pechanova O, Bernatova I, Babal P et al. Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension. J Hypertens 2004 August;22(8):1551-9. (491)Plotnikov MB, Aliev OI, Vasil'ev AS et al. [The hemorheological effects of Lychnis chalcedonica L. extracts]. Eksp Klin Farmakol 2000 March;63(2):54-6. (492)Zhang J, Fu S, Liu S, Mao T, Xiu R. The therapeutic effect of Ginkgo biloba extract in SHR rats and its possible mechanisms based on cerebral microvascular flow and vasomotion. Clin Hemorheol Microcirc 2000;23(2-4):133-8. (493)Gohil K, Packer L. Bioflavonoid-rich botanical extracts show antioxidant and gene regulatory activity. Ann N Y Acad Sci 2002 May;957:70-7. (494)Lotito SB, Frei B. The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids. Free Radic Biol Med 2004 July 15;37(2):251-8. (495)Murakami A, Nakamura Y, Ohto Y et al. Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoid. Biofactors 2000;12(1-4):187-92. (496)Noda Y, Anzai K, Mori A, Kohno M, Shinmei M, Packer L. Hydroxyl and superoxide anion radical scavenging activities of natural source antioxidants using the computerized JES-FR30 ESR spectrometer system. Biochem Mol Biol Int 1997 June;42(1):35-44. (497)bu-Amsha CR, Burke V, Mori TA, Beilin LJ, Puddey IB, Croft KD. Red wine polyphenols, in the absence of alcohol, reduce lipid peroxidative stress in smoking subjects. Free Radic Biol Med 2001 March 15;30(6):636-42. (498)Rodrigo R, Rivera G, Orellana M, Araya J, Bosco C. Rat kidney antioxidant response to long-term exposure to flavonol rich red wine. Life Sci 2002 November 1;71(24):2881-95. (499)Sartelet H, Serghat S, Lobstein A et al. Flavonoids extracted from fonio millet (Digitaria exilis) reveal potent antithyroid properties. Nutrition 1996 February;12(2):100-6. (500)Rein D, Paglieroni TG, Pearson DA et al. Cocoa and wine polyphenols modulate platelet activation and function. J Nutr 2000 August;130(8S Suppl):2120S-6S. (501)Wan Y, Vinson JA, Etherton TD, Proch J, Lazarus SA, Kris-Etherton PM. Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. Am J Clin Nutr 2001 November;74(5):596-602. (502)Cardillo C, Kilcoyne CM, Cannon RO, III, Panza JA. Impairment of the nitric oxide-mediated vasodilator response to mental stress in hypertensive but not in hypercholesterolemic patients. J Am Coll Cardiol 1998 November;32(5):1207-13. (503)Dandona P, Chaudhuri A, Aljada A. Endothelial dysfunction and hypertension in diabetes mellitus. Med Clin North Am 2004 July;88(4):911-xi. (504)de lR, I, Roson MI, Vega GW et al. Effect of oral L-arginine administration for three weeks in two kidney-two clip hypertensive rats. Arch Physiol Biochem 2000 December;108(5):415-21. (505)de Wardener HE. The hypothalamus and hypertension. Physiol Rev 2001 October;81(4):1599-658. (506)Dell'Omo G, Penno G, Pucci L, Mariani M, Del PS, Pedrinelli R. Abnormal capillary permeability and endothelial dysfunction in hypertension with comorbid Metabolic Syndrome. Atherosclerosis 2004 February;172(2):383-9. (507)Gerova M. Acetylcholine and bradykinin induce paradoxically amplified hypotensive response in hypertensive NO-deficient rats. Physiol Res 1999;48(4):249-57. (508)GREDER G. [Preliminary clinical study of a new hypotensive drug, nitrocholine.]. Schweiz Med Wochenschr 1955 August 13;85(33):796-8. (509)GROLLMAN A, WHITE FN. Induction of renal hypertension in rats and dogs by potassium or choline deficiency. Am J Physiol 1958 April;193(1):144-6. (510)HANDLER P, BERNHEIM F. Effect of renal decapsulation on hypertension induced by single episode of acute choline deficiency. Proc Soc Exp Biol Med 1951 February;76(2):338-41. (511)HANDLER P, BERNHEIM F. Influence of dietary factors on hypertension induced by choline deficiency. Am J Physiol 1950 July 1;162(1):189-92. (512)HANDLER P, BERNHEIM F. Influence of dietary factors on hypertension induced by choline deficiency. Am J Physiol 1950 July 1;162(1):189-92. (513)Hayakawa H, Raij L. Relationship between hypercholesterolaemia, endothelial dysfunction and hypertension. J Hypertens 1999 May;17(5):611-9. (514)Higashi Y, Sasaki S, Nakagawa K et al. Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals. Am J Hypertens 2002 April;15(4 Pt 1):326-32. (515)Hoffman WE, Schmid PG, Phillips MI. Central cholinergic and noradrenergic stimulation in spontaneously hypertensive rats. J Pharmacol Exp Ther 1978 September;206(3):644-51. (516)Jiang Z, Lei Y, Gu K, Xianghua J, Liming X, Kejian H. The influences of NO and Ach on cGMP levels in two patient populations. J Extra Corpor Technol 2001 February;33(1):23-6. (517)Kato Y, Kijima Y, Kitakaze M et al. Roles of systemic nitric oxide metabolites for human coronary circulation. Cardiovasc Drugs Ther 2004 May;18(3):189-95. (518)KOYANAGI T, HAREYAMA S. Effect of choline on the hypertension of rats induced by high salt diet. J Vitaminol (Kyoto) 1957 December 10;3(4):303-6. (519)Kratzing CC, Wetzig GA, Ellway CP. Adrenergic mechanisms in choline-deficient rats. J Nutr 1970 July;100(7):781-5. (520)Kratzing CC, Perry JJ, Ellway CP, Wetzig GA. Kidney function during choline deficiency. Pathology 1972 January;4(1):53-9. (521)Kratzing CC, Perry JJ. Hypertension in young rats following choline deficiency in maternal diets. J Nutr 1971 December;101(12):1657-61. (522)Kubo T, Fukumori R, Kobayashi M, Yamaguchi H. Altered cholinergic mechanisms and blood pressure regulation in the rostral ventrolateral medulla of DOCA-salt hypertensive rats. Brain Res Bull 1998;45(3):327-32. (523)Kuksis A, Mookerjea S. Choline. Nutr Rev 1978 July;36(7):201-7. (524)Mangos GJ, Walker BR, Kelly JJ, Lawson JA, Webb DJ, Whitworth JA. Cortisol inhibits cholinergic vasodilation in the human forearm. Am J Hypertens 2000 November;13(11):1155-60. (525)McAllister AS, Atkinson AB, Johnston GD, Hadden DR, Bell PM, McCance DR. Basal nitric oxide production is impaired in offspring of patients with essential hypertension. Clin Sci (Lond) 1999 August;97(2):141-7. (526)Rizzoni D, gabiti-Rosei E. Endothelial factors and microvascular hypertensive disease. J Cardiovasc Pharmacol 2001 November;38 Suppl 2:S15-S18. (527)ROCHE J, NGUYEN-VAN THOA, NGUYEN-VAN THEI. [Pyrophosphorylcholine and cophosphatase.]. Bull Soc Chim Biol (Paris) 1952 May;34(5-6):486-90. (528)L-arginine-derived nitric oxide and the cell-mediated immune response. 39th Forum in Immunology. Res Immunol 1991 September;142(7):551-602. (529)Does supplemental arginine alter immune function following major surgery? Nutr Rev 1993 February;51(2):54-6. (530)Abbasi F, Asagmi T, Cooke JP et al. Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus. Am J Cardiol 2001 November 15;88(10):1201-3. (531)Albertini M, Clement MG. In pigs, inhaled nitric oxide (NO) counterbalances PAF-induced pulmonary hypertension. Prostaglandins Leukot Essent Fatty Acids 1994 November;51(5):357-62. (532)Alexander JW. Specific nutrients and the immune response. Nutrition 1995 March;11(2 Suppl):229-32. (533)Angele MK, Smail N, Ayala A, Cioffi WG, Bland KI, Chaudry IH. L-arginine: a unique amino acid for restoring the depressed macrophage functions after trauma-hemorrhage. J Trauma 1999 January;46(1):34-41. (534)Angele MK, Fitzal F, Smail N et al. L-arginine attenuates trauma-hemorrhage-induced liver injury. Crit Care Med 2000 September;28(9):3242-8. (535)Arnal JF, Dinh-Xuan AT, Pueyo M, Darblade B, Rami J. Endothelium-derived nitric oxide and vascular physiology and pathology. Cell Mol Life Sci 1999 July;55(8-9):1078-87. (536)Ashutosh K. Nitric oxide and asthma: a review. Curr Opin Pulm Med 2000 January;6(1):21-5. (537)Boer J, Duyvendak M, Schuurman FE, Pouw FM, Zaagsma J, Meurs H. Role of L-arginine in the deficiency of nitric oxide and airway hyperreactivity after the allergen-induced early asthmatic reaction in guinea-pigs. Br J Pharmacol 1999 November;128(5):1114-20. (538)Boer J, Duyvendak M, Schuurman FE, Pouw FM, Zaagsma J, Meurs H. Role of L-arginine in the deficiency of nitric oxide and airway hyperreactivity after the allergen-induced early asthmatic reaction in guinea-pigs. Br J Pharmacol 1999 November;128(5):1114-20. (539)Castillo L, DeRojas-Walker T, Yu YM et al. Whole body arginine metabolism and nitric oxide synthesis in newborns with persistent pulmonary hypertension. Pediatr Res 1995 July;38(1):17-24. (540)Cen Y, Luo XS, Liu XX. [Effect of L-arginine supplementation on partial-thickness burned patients]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 1999 July;13(4):227-31. (541)Cerra FB. Nutrient modulation of inflammatory and immune function. Am J Surg 1991 February;161(2):230-4. (542)Cooke JP, Andon NA, Girerd XJ, Hirsch AT, Creager MA. Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta. Circulation 1991 March;83(3):1057-62. (543)Cooke JP, Dzau J, Creager A. Endothelial dysfunction in hypercholesterolemia is corrected by L-arginine. Basic Res Cardiol 1991;86 Suppl 2:173-81. (544)Cooke JP, Tsao PS. Arginine: a new therapy for atherosclerosis? Circulation 1997 January 21;95(2):311-2. (545)Cooke JP. Nutriceuticals for cardiovascular health. Am J Cardiol 1998 November 19;82(10A):43S-6S. (546)Cooke JP, Losordo DW. Nitric oxide and angiogenesis. Circulation 2002 May 7;105(18):2133-5. (547)Cooke JP. A novel mechanism for pulmonary arterial hypertension? Circulation 2003 September 23;108(12):1420-1. (548)Creager MA, Gallagher SJ, Girerd XJ, Coleman SM, Dzau VJ, Cooke JP. L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest 1992 October;90(4):1248-53. (549)Cremona G, Wood AM, Hall LW, Bower EA, Higenbottam T. Effect of inhibitors of nitric oxide release and action on vascular tone in isolated lungs of pig, sheep, dog and man. J Physiol 1994 November 15;481 ( Pt 1):185-95. (550)de Gouw HW, Verbruggen MB, Twiss IM, Sterk PJ. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax 1999 November;54(11):1033-5. (551)de Gouw HW, Marshall-Partridge SJ, van d, V, Van Den Aardweg JG, Hiemstra PS, Sterk PJ. Role of nitric oxide in the airway response to exercise in healthy and asthmatic subjects. J Appl Physiol 2001 February;90(2):586-92. (552)Efron DT, Barbul A. Modulation of inflammation and immunity by arginine supplements. Curr Opin Clin Nutr Metab Care 1998 November;1(6):531-8. (553)Efron DT, Barbul A. Arginine and immunonutrition: a reevaluation. Nutrition 2000 January;16(1):73-4. (554)Evoy D, Lieberman MD, Fahey TJ, III, Daly JM. Immunonutrition: the role of arginine. Nutrition 1998 July;14(7-8):611-7. (555)Fagan JM, Rex SE, Hayes-Licitra SA, Waxman L. L-arginine reduces right heart hypertrophy in hypoxia-induced pulmonary hypertension. Biochem Biophys Res Commun 1999 January 8;254(1):100-3. (556)Field CJ, Johnson I, Pratt VC. Glutamine and arginine: immunonutrients for improved health. Med Sci Sports Exerc 2000 July;32(7 Suppl):S377-S388. (557)Galie N, Manes A, Branzi A. Emerging medical therapies for pulmonary arterial hypertension. Prog Cardiovasc Dis 2002 November;45(3):213-24. (558)Gonce SJ, Peck MD, Alexander JW, Miskell PW. Arginine supplementation and its effect on established peritonitis in guinea pigs. JPEN J Parenter Enteral Nutr 1990 May;14(3):237-44. (559)Akesson B, Panagiotidis G, Westermark P, Lundquist I. Islet amyloid polypeptide inhibits glucagon release and exerts a dual action on insulin release from isolated islets. Regul Pept 2003 March 28;111(1-3):55-60. (560)Bernatova I, Pechanova O, Pelouch V, Simko F. Regression of chronic L -NAME-treatment-induced left ventricular hypertrophy: effect of captopril. J Mol Cell Cardiol 2000 February;32(2):177-85. (561)Boer J, Duyvendak M, Schuurman FE, Pouw FM, Zaagsma J, Meurs H. Role of L-arginine in the deficiency of nitric oxide and airway hyperreactivity after the allergen-induced early asthmatic reaction in guinea-pigs. Br J Pharmacol 1999 November;128(5):1114-20. (562)Boonstra AH, Gschwend S, Kocks MJ, Buikema H, De Zeeuw D, Navis GJ. Does a low-salt diet exert a protective effect on endothelial function in normal rats? J Lab Clin Med 2001 September;138(3):200-5. (563)Brandes RP, Schmitz-Winnenthal FH, Feletou M et al. An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice. Proc Natl Acad Sci U S A 2000 August 15;97(17):9747-52. (564)Garcia-Robles R, Villa E, Serrano J, Escobar-Morreale HF, Piedrola G, Ruilope LM. Effects of L-arginine infusion on renal hemodynamics and sodium excretion during hypo-, normo-, and hyperinsulinemia, as studied in dogs. Am J Hypertens 1996 July;9(7):681-6. (565)Jang JJ, Ho HK, Kwan HH, Fajardo LF, Cooke JP. Angiogenesis is impaired by hypercholesterolemia: role of asymmetric dimethylarginine. Circulation 2000 September 19;102(12):1414-9. (566)Maxwell AJ, Schauble E, Bernstein D, Cooke JP. Limb blood flow during exercise is dependent on nitric oxide. Circulation 1998 July 28;98(4):369-74. (567)Meurs H, McKay S, Maarsingh H et al. Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness. Br J Pharmacol 2002 June;136(3):391-8. (568)Schuschke DA, Falcone JC, Saari JT et al. Endothelial cell calcium mobilization to acetylcholine is attenuated in copper-deficient rats. Endothelium 2000;7(2):83-92. (569)Bonina L, Nash AA, Arena A, Leung KN, Wildy P. T cell-macrophage interaction in arginase-mediated resistance to herpes simplex virus. Virus Res 1984 September;1(6):501-5. (570)Denis M. Tumor necrosis factor and granulocyte macrophage-colony stimulating factor stimulate human macrophages to restrict growth of virulent Mycobacterium avium and to kill avirulent M. avium: killing effector mechanism depends on the generation of reactive nitrogen intermediates. J Leukoc Biol 1991 April;49(4):380-7. (571)Espanol A, Eijan AM, Mazzoni E et al. Nitric oxide synthase, arginase and cyclooxygenase are involved in muscarinic receptor activation in different murine mammary adenocarcinoma cell lines. Int J Mol Med 2002 June;9(6):651-7. (572)Gobert AP, McGee DJ, Akhtar M et al. Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: a strategy for bacterial survival. Proc Natl Acad Sci U S A 2001 November 20;98(24):13844-9. (573)Hammermann R, Hirschmann J, Hey C et al. Cationic proteins inhibit L-arginine uptake in rat alveolar macrophages and tracheal epithelial cells. Implications for nitric oxide synthesis. Am J Respir Cell Mol Biol 1999 August;21(2):155-62. (574)Hammermann R, Hirschmann J, Hey C et al. Cationic proteins inhibit L-arginine uptake in rat alveolar macrophages and tracheal epithelial cells. Implications for nitric oxide synthesis. Am J Respir Cell Mol Biol 1999 August;21(2):155-62. (575)Huang J, DeGraves FJ, Lenz SD et al. The quantity of nitric oxide released by macrophages regulates Chlamydia-induced disease. Proc Natl Acad Sci U S A 2002 March 19;99(6):3914-9. (576)Hutchison SJ, Sievers RE, Zhu BQ et al. Secondhand tobacco smoke impairs rabbit pulmonary artery endothelium-dependent relaxation. Chest 2001 December;120(6):2004-12. (577)James SL, Glaven JA. Effects of inhibitors of tumoricidal activity upon schistosomulum killing by activated macrophages. Infect Immun 1987 December;55(12):3174-80. (578)Kung JT, Brooks SB, Jakway JP, Leonard LL, Talmage DW. Suppression of in vitro cytotoxic response by macrophages due to induced arginase. J Exp Med 1977 September 1;146(3):665-72. (579)Langle F, Roth E, Steininger R, Winkler S, Muhlbacher F. Arginase release following liver reperfusion. Evidence of hemodynamic action of arginase infusions. Transplantation 1995 June 15;59(11):1542-9. (580)Langle F, Roth E, Steininger R, Winkler S, Muhlbacher F. Arginase release following liver reperfusion. Evidence of hemodynamic action of arginase infusions. Transplantation 1995 June 15;59(11):1542-9. (581)Martin-Sanz P, Bosca L, Olmedilla L et al. Presence of a nitric oxide synthase inhibitor in the graft efflux during reperfusion in human liver transplantation. Clin Transplant 1999 June;13(3):221-30. (582)Meurs H, McKay S, Maarsingh H et al. Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness. Br J Pharmacol 2002 June;136(3):391-8. (583)Meurs H, McKay S, Maarsingh H et al. Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness. Br J Pharmacol 2002 June;136(3):391-8. (584)Meurs H, Maarsingh H, Zaagsma J. Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness. Trends Pharmacol Sci 2003 September;24(9):450-5. (585)Morris CR, Morris SM, Jr., Hagar W et al. Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease? Am J Respir Crit Care Med 2003 July 1;168(1):63-9. (586)Olds GR, Ellner JJ, Kearse LA, Jr., Kazura JW, Mahmoud AA. Role of arginase in killing of schistosomula of Schistosoma mansoni. J Exp Med 1980 June 1;151(6):1557-62. (587)Pereira CA, Soler G, Modolell M. Anti-MHV3 state induced by IFN gamma in macrophages is not related to arginine metabolism. Arch Virol 1997;142(10):2001-10. (588)Sahach VF, Baziliuk OV, Kotsiuruba AV, Buzhanevich OM. [Disorders of endothelium-dependent vascular reactions and of the arginase and NO-synthase pathways of L-arginine metabolism in arterial hypertension]. Fiziol Zh 2000;46(3):3-13. (589)Todd CD, Cooke JE, Mullen RT, Gifford DJ. Regulation of loblolly pine (Pinus taeda L.) arginase in developing seedling tissue during germination and post-germinative growth. Plant Mol Biol 2001 March;45(5):555-65. (590)Vercelli D. Arginase: marker, effector, or candidate gene for asthma? J Clin Invest 2003 June;111(12):1815-7. (591)Zimmermann N, King NE, Laporte J et al. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest 2003 June;111(12):1863-74. (592)Attia DM, Verhagen AM, Stroes ES et al. Vitamin E alleviates renal injury, but not hypertension, during chronic nitric oxide synthase inhibition in rats. J Am Soc Nephrol 2001 December;12(12):2585-93. (593)Bulbuller N, Dogru O, Umac H, Gursu F, Akpolat N. [The effects of melatonin and pentoxiphylline on L-arginine induced acute pancreatitis]. Ulus Travma Derg 2005 April;11(2):108-14. (594)Ceylan E, Aksoy N, Gencer M, Vural H, Keles H, Selek S. Evaluation of oxidative-antioxidative status and the L-arginine-nitric oxide pathway in asthmatic patients. Respir Med 2005 July;99(7):871-6. (595)Chagan L, Ioselovich A, Asherova L, Cheng JW. Use of alternative pharmacotherapy in management of cardiovascular diseases. Am J Manag Care 2002 March;8(3):270-85. (596)Dulak J, Jozkowicz A, Dembinska-Kiec A et al. Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2000 March;20(3):659-66. (597)Fadillioglu E, Erdogan H, Polat A, Emre MH. Renal antioxidant status in rats with hypertension induced by N sup omega nitro-L-arginine methyl ester. Kidney Blood Press Res 2002;25(4):211-6. (598)Fukuda Y, Teragawa H, Matsuda K, Yamagata T, Matsuura H, Chayama K. Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia. Heart 2002 March;87(3):264-9. (599)Heitzer T, Brockhoff C, Mayer B et al. Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase. Circ Res 2000 February 4;86(2):E36-E41. (600)Keegan A, Cotter MA, Cameron NE. Corpus cavernosum dysfunction in diabetic rats: effects of combined alpha-lipoic acid and gamma-linolenic acid treatment. Diabetes Metab Res Rev 2001 September;17(5):380-6. (601)Khattab M, Ahmad M, Al-Shabanah OA, Raza M. Effects of losartan on blood pressure, oxidative stress, and nitrate/nitrite levels in the nitric oxide deficient hypertensive rats. Receptors Channels 2004;10(5-6):147-57. (602)Laight DW, Desai KM, Anggard EE, Carrier MJ. Endothelial dysfunction accompanies a pro-oxidant, pro-diabetic challenge in the insulin resistant, obese Zucker rat in vivo. Eur J Pharmacol 2000 August 18;402(1-2):95-9. (603)Laight DW, Desai KM, Anggard EE, Carrier MJ. Endothelial dysfunction accompanies a pro-oxidant, pro-diabetic challenge in the insulin resistant, obese Zucker rat in vivo. Eur J Pharmacol 2000 August 18;402(1-2):95-9. (604)Liu F, Jan KY. DNA damage in arsenite- and cadmium-treated bovine aortic endothelial cells. Free Radic Biol Med 2000 January 1;28(1):55-63. (605)Lundman P, Tornvall P, Nilsson L, Pernow J. A triglyceride-rich fat emulsion and free fatty acids but not very low density lipoproteins impair endothelium-dependent vasorelaxation. Atherosclerosis 2001 November;159(1):35-41. (606)Maffei A, Poulet R, Vecchione C et al. Increased basal nitric oxide release despite enhanced free radical production in hypertension. J Hypertens 2002 June;20(6):1135-42. (607)Maffei A, Poulet R, Vecchione C et al. Increased basal nitric oxide release despite enhanced free radical production in hypertension. J Hypertens 2002 June;20(6):1135-42. (608)Mochizuki S, Himi N, Miyasaka T et al. Evaluation of basic performance and applicability of a newly developed in vivo nitric oxide sensor. Physiol Meas 2002 May;23(2):261-8. (609)On YK, Kim HS, Kim SY et al. Vitamin C prevents radiation-induced endothelium-dependent vasomotor dysfunction and de-endothelialization by inhibiting oxidative damage in the rat. < | |||||||
